User profiles for J. Kleinjung

Jens Kleinjung

Sosei Heptares
Verified email at jkleinj.eu
Cited by 2885

Design and application of implicit solvent models in biomolecular simulations

J Kleinjung, F Fraternali - Current opinion in structural biology, 2014 - Elsevier
… the GB pair terms between charged atoms or atom groups i and j:(11) Δ G s o l v = − 1 2 1 ∈
int − 1 ∈ e x t q i q j r i j 2 + α i α j e − r i j 2 / 4 α i α j . Zhu et al. [35] implemented different GB …

Genome editing reveals a role for OCT4 in human embryogenesis

…, SE Wamaitha, D Kim, V Maciulyte, J Kleinjung… - Nature, 2017 - nature.com
Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …

[HTML][HTML] In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm …

…, Y Huang, J Kleinjung, V Wilson, J Briscoe - PLoS …, 2014 - journals.plos.org
Cells of the spinal cord and somites arise from shared, dual-fated precursors, located
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …

[PDF][PDF] A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development

…, Y Huang, J Kleinjung, V Wilson, J Briscoe - Developmental cell, 2017 - cell.com
Transcriptional networks, regulated by extracellular signals, control cell fate decisions and
determine the size and composition of developing tissues. One example is the network …

POPS: a fast algorithm for solvent accessible surface areas at atomic and residue level

L Cavallo, J Kleinjung, F Fraternali - Nucleic acids research, 2003 - academic.oup.com
… The term b ij (r ij ) represents the SASA removed from S i by the overlap of the atoms i
and j at a distance r ij =|r i −r j |. If r ij >R i +R j +2R solv … while if r ij <R i +R j +2R solv …

Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

R Lasrado, W Boesmans, J Kleinjung, C Pin, D Bell… - Science, 2017 - science.org
The enteric nervous system (ENS) is essential for digestive function and gut homeostasis.
Here we show that the amorphous neuroglia networks of the mouse ENS are composed of …

Homology-extended sequence alignment

VA Simossis, J Kleinjung, J Heringa - Nucleic acids research, 2005 - academic.oup.com
We present a profile–profile multiple alignment strategy that uses database searching to
collect homologues for each sequence in a given set, in order to enrich their available …

[PDF][PDF] Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics

A Pandini, A Fornili, F Fraternali, J Kleinjung - Biophysical Journal, 2012 - cell.com
Methods First, MD ensembles are mapped onto a canonical set of representative fragments,
ie a set of discrete 4-residue states [3]. By this mapping, the contribution of rigid fragment …

[HTML][HTML] A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

…, AC Bon-Frauches, EM Amaniti, J Kleinjung… - Nature …, 2023 - nature.com
Glial cells have been proposed as a source of neural progenitors, but the mechanisms
underpinning the neurogenic potential of adult glia are not known. Using single cell …

An overview of multiple sequence alignment

…, J Kleinjung, J Heringa - Current protocols in …, 2003 - Wiley Online Library
… This is referred to as the SP score for alignment: for each amino acid a i,j in sequence i and
at position j in the MSA, the SP score is S(j) = Σ k<l s(a k,j , a l,j ), where s(a k,j , a l,j ) is the …