User profiles for J. Kleinjung
Jens KleinjungSosei Heptares Verified email at jkleinj.eu Cited by 2885 |
Design and application of implicit solvent models in biomolecular simulations
J Kleinjung, F Fraternali - Current opinion in structural biology, 2014 - Elsevier
… the GB pair terms between charged atoms or atom groups i and j:(11) Δ G s o l v = − 1 2 1 ∈
int − 1 ∈ e x t q i q j r i j 2 + α i α j e − r i j 2 / 4 α i α j . Zhu et al. [35] implemented different GB …
int − 1 ∈ e x t q i q j r i j 2 + α i α j e − r i j 2 / 4 α i α j . Zhu et al. [35] implemented different GB …
Genome editing reveals a role for OCT4 in human embryogenesis
Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …
regulate the first cell fate decisions in the human embryo are not well understood. Here we …
[HTML][HTML] In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm …
…, Y Huang, J Kleinjung, V Wilson, J Briscoe - PLoS …, 2014 - journals.plos.org
Cells of the spinal cord and somites arise from shared, dual-fated precursors, located
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …
[PDF][PDF] A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development
…, Y Huang, J Kleinjung, V Wilson, J Briscoe - Developmental cell, 2017 - cell.com
Transcriptional networks, regulated by extracellular signals, control cell fate decisions and
determine the size and composition of developing tissues. One example is the network …
determine the size and composition of developing tissues. One example is the network …
POPS: a fast algorithm for solvent accessible surface areas at atomic and residue level
… The term b ij (r ij ) represents the SASA removed from S i by the overlap of the atoms i
and j at a distance r ij =|r i −r j |. If r ij >R i +R j +2R solv … while if r ij <R i +R j +2R solv …
and j at a distance r ij =|r i −r j |. If r ij >R i +R j +2R solv … while if r ij <R i +R j +2R solv …
Lineage-dependent spatial and functional organization of the mammalian enteric nervous system
The enteric nervous system (ENS) is essential for digestive function and gut homeostasis.
Here we show that the amorphous neuroglia networks of the mouse ENS are composed of …
Here we show that the amorphous neuroglia networks of the mouse ENS are composed of …
Homology-extended sequence alignment
VA Simossis, J Kleinjung, J Heringa - Nucleic acids research, 2005 - academic.oup.com
We present a profile–profile multiple alignment strategy that uses database searching to
collect homologues for each sequence in a given set, in order to enrich their available …
collect homologues for each sequence in a given set, in order to enrich their available …
[PDF][PDF] Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics
Methods First, MD ensembles are mapped onto a canonical set of representative fragments,
ie a set of discrete 4-residue states [3]. By this mapping, the contribution of rigid fragment …
ie a set of discrete 4-residue states [3]. By this mapping, the contribution of rigid fragment …
[HTML][HTML] A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia
…, AC Bon-Frauches, EM Amaniti, J Kleinjung… - Nature …, 2023 - nature.com
Glial cells have been proposed as a source of neural progenitors, but the mechanisms
underpinning the neurogenic potential of adult glia are not known. Using single cell …
underpinning the neurogenic potential of adult glia are not known. Using single cell …
An overview of multiple sequence alignment
…, J Kleinjung, J Heringa - Current protocols in …, 2003 - Wiley Online Library
… This is referred to as the SP score for alignment: for each amino acid a i,j in sequence i and
at position j in the MSA, the SP score is S(j) = Σ k<l s(a k,j , a l,j ), where s(a k,j , a l,j ) is the …
at position j in the MSA, the SP score is S(j) = Σ k<l s(a k,j , a l,j ), where s(a k,j , a l,j ) is the …