Brain tumors are common, requiring general medical providers to have a basic understanding
of their diagnosis and management. The most prevalent brain tumors are intracranial …

A high tumour mutational burden (hypermutation) is observed in some gliomas 1 , 2 , 3 , 4 –
5 ; however, the mechanisms by which hypermutation develops and whether it predicts the …

Although we can increasingly measure transcription, chromatin, methylation, and other
aspects of molecular biology at single-cell resolution, most assays survey only one aspect of …

Linking regulatory DNA elements to their target genes, which may be located hundreds of
kilobases away, remains challenging. Here, we introduce Cicero, an algorithm that identifies co…

Over one million candidate regulatory elements have been identified across the human
genome, but nearly all are unvalidated and their target genes uncertain. Approaches based on …

Single cell RNA sequencing can yield high-resolution cell-type–specific expression signatures
that reveal new cell types and the developmental trajectories of cell lineages. Here, we …

High-throughput chemical screens typically use coarse assays such as cell survival, limiting
what can be learned about mechanisms of action, off-target effects, and heterogeneous …

… McFaline-Figueroa and Jason D. Vevea contributed equally to the development of this work,
including concept development, method development, data acquisition, data analysis and …

Single-cell genomic approaches have the potential to revolutionize the study of plant
systems. Here, we highlight newly developed techniques to analyze transcriptomes at single-cell …

Several groups recently coupled CRISPR perturbations and single-cell RNA-seq for pooled
genetic screens. We demonstrate that vector designs of these studies are susceptible to ∼50…