[PDF][PDF] The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations

…, J Stocksdale, MS Casale, TG Thompson, J Wu… - Cell systems, 2018 - cell.com
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …

[PDF][PDF] Mutant huntingtin disrupts the nuclear pore complex

…, J Ochaba, C Geater, E Morozko, J Stocksdale… - Neuron, 2017 - cell.com
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT)
gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. …

[PDF][PDF] Huntington's disease iPSC-derived brain microvascular endothelial cells reveal WNT-mediated angiogenic and blood-brain barrier deficits

…, TA Gipson, J Wu, GD Vatine, J Stocksdale… - Cell reports, 2017 - cell.com
Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain
barrier (BBB) that shields the brain against toxins and immune cells. While BBB …

[HTML][HTML] Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

…, J Roggenbuck, MB Harms, J Stocksdale… - Nature …, 2022 - nature.com
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent
stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and …

[HTML][HTML] A comparison of mRNA sequencing with random primed and 3′-directed libraries

…, J Bochicchio, L Lenaeus, J Stocksdale, J Shim… - Scientific reports, 2017 - nature.com
Creating a cDNA library for deep mRNA sequencing (mRNAseq) is generally done by
random priming, creating multiple sequencing fragments along each transcript. A 3′-end-focused …

[PDF][PDF] An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

…, D Ramamoorthy, K Sachs, B Shelley, J Stocksdale… - Iscience, 2021 - cell.com
Neurodegenerative diseases are challenging for systems biology because of the lack of
reliable animal models or patient samples at early disease stages. Induced pluripotent stem …

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-human ACE2 transgenic mice

…, J Wu, MS Burns, KI Tsourmas, J Stocksdale… - Journal of …, 2022 - Am Soc Microbiol
Unlike SARS-CoV-1 and MERS-CoV, infection with SARS-CoV-2, the viral pathogen
responsible for COVID-19, is often associated with neurologic symptoms that range from mild to …

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease

…, J Zaifman, A Hill, JT Stocksdale… - Proceedings of the …, 2021 - National Acad Sciences
DNA damage repair genes are modifiers of disease onset in Huntington’s disease (HD), but
how this process intersects with associated disease pathways remains unclear. Here we …

[PDF][PDF] Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation

…, SJ Hernandez, RG Lim, M Adam, J Wu, JT Stocksdale… - Stem cell reports, 2020 - cell.com
Aberrant neuronal development and the persistence of mitotic cellular populations have
been implicated in a multitude of neurological disorders, including Huntington's disease (HD). …

[HTML][HTML] Analysis of allele-specific RNA transcription in FSHD by RNA-DNA FISH in single myonuclei

…, R Tawil, LF Lock, JE Hewitt, J Stocksdale… - European Journal of …, 2010 - nature.com
Autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) is likely caused by
epigenetic alterations in chromatin involving contraction of the D4Z4 repeat array near the …