Mitochondrial proton and electron leak have a major impact on mitochondrial coupling
efficiency and production of reactive oxygen species. In the first part of this chapter, we address …

… Treberg; A radical shift in perspective: mitochondria as regulators of reactive oxygen
species. J Exp Biol 1 April 2017; 220 (7): 1170–1180. doi: https://doi.org/10.1242/jeb.132142 …

At its core mitochondrial function relies on redox reactions. Electrons stripped from nutrients
are used to form NADH and NADPH, electron carriers that are similar in structure but support …

Respiratory complex II oxidizes succinate to fumarate as part of the Krebs cycle and reduces
ubiquinone in the electron transport chain. Previous experimental evidence suggested that …

Complex I (NADH-ubiquinone oxidoreductase) can form superoxide during forward electron
flow (NADH-oxidizing) or, at sufficiently high protonmotive force, during reverse electron …

Superoxide production from antimycin-inhibited complex III in isolated mitochondria first
increased to a maximum then decreased as substrate supply was modulated in three different …

Individual sites of superoxide production in the mitochondrial respiratory chain have
previously been defined and partially characterized using specific inhibitors, but the native …

The unusual energy metabolism of elasmobranchs is characterized by limited or absent fatty
acid oxidation in cardiac and skeletal muscle and a great reliance on ketone bodies and …

… We have confirmed similarly low respiration independent H 2 O 2 decomposition in trout
muscle mitochondria (Zacharias and Treberg unpublished). As such, we assume the influence …

… (Munro & Treberg, 2017; Treberg et al., 2015), providing an oxidant index. Figure 6a,b shows
that the oxidant index of skeletal muscle mitochondria is substantially lower for NMRs in all …