[HTML][HTML] Trade-offs between gene expression, growth and phenotypic diversity in microbial populations
… Author links open overlay panel Juhyun Kim 1 4 , Alexander Darlington 2 4 , Manuel
Salvador 1 , José Utrilla 3 , José I … Mondragón-Palomino, RJ Williams, LS Tsimring, J. Hasty …
Salvador 1 , José Utrilla 3 , José I … Mondragón-Palomino, RJ Williams, LS Tsimring, J. Hasty …
Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium
Adaptive laboratory evolution (ALE) has emerged as an effective tool for scientific discovery
and addressing biotechnological needs. Much of ALE's utility is derived from reproducibly …
and addressing biotechnological needs. Much of ALE's utility is derived from reproducibly …
[HTML][HTML] Quantification and Classification of E. coli Proteome Utilization and Unused Protein Costs across Environments
EJ O'Brien, J Utrilla, BO Palsson - PLoS computational biology, 2016 - journals.plos.org
The costs and benefits of protein expression are balanced through evolution. Expression of
un-utilized protein (that have no benefits in the current environment) incurs a quantifiable …
un-utilized protein (that have no benefits in the current environment) incurs a quantifiable …
[HTML][HTML] Global rebalancing of cellular resources by pleiotropic point mutations illustrates a multi-scale mechanism of adaptive evolution
Pleiotropic regulatory mutations affect diverse cellular processes, posing a challenge to our
understanding of genotype-phenotype relationships across multiple biological scales. …
understanding of genotype-phenotype relationships across multiple biological scales. …
Selection of heterogeneous catalysts for biodiesel production from animal fat
…, MF Almeida, JDM Díaz, MS Polo, JR Utrilla - Fuel, 2012 - Elsevier
… Méndez Díaz b , Manuel Sánchez Polo b , José Rivera Utrilla b … ∑ i = 1 3 β i x i + ∑ i = 1 3
β ii x i 2 + ∑ i = 1 2 ∑ j = i + 1 3 β ij x i x j … J Chem Technol Biotechnol, 83 (2008), pp. 862-870 …
β ii x i 2 + ∑ i = 1 2 ∑ j = i + 1 3 β ij x i x j … J Chem Technol Biotechnol, 83 (2008), pp. 862-870 …
Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance
…, I Cruz-Chamorro, A López-González, JC Utrilla… - Brain, behavior, and …, 2015 - Elsevier
Experimental autoimmune encephalomyelitis (EAE), the experimental model for multiple
sclerosis (MS), is triggered by myelin-specific Th1 and Th17 cells. The immunomodulatory …
sclerosis (MS), is triggered by myelin-specific Th1 and Th17 cells. The immunomodulatory …
Model-driven discovery of underground metabolic functions in Escherichia coli
Enzyme promiscuity toward substrates has been discussed in evolutionary terms as
providing the flexibility to adapt to novel environments. In the present work, we describe an …
providing the flexibility to adapt to novel environments. In the present work, we describe an …
Dietary extra virgin olive oil attenuates kidney injury in pristane-induced SLE model via activation of HO-1/Nrf-2 antioxidant pathway and suppression of JAK/STAT, NF …
…, MÁ Rosillo, S Sánchez-Fidalgo, J Utrilla… - The Journal of …, 2016 - Elsevier
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a
widespread organ involvement. Recent studies have suggested that extra virgin olive oil (EVOO) …
widespread organ involvement. Recent studies have suggested that extra virgin olive oil (EVOO) …
Biodiesel production using calcium manganese oxide as catalyst and different raw materials
…, MF Almeida, JDM Díaz, MS Polo, JR Utrilla - Energy conversion and …, 2013 - Elsevier
The use of heterogeneous catalysts for biodiesel production aims to simplify the production
process as well as to reduce purification costs and related environmental impacts. Calcium …
process as well as to reduce purification costs and related environmental impacts. Calcium …
Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter
Despite the abundance of xylose in nature, the production of chemicals from C5 sugars
remains challenging in metabolic engineering. By deleting xylFGH genes and using adaptive …
remains challenging in metabolic engineering. By deleting xylFGH genes and using adaptive …