Retinal ischemia is a common cause of visual impairment and blindness. At the cellular level,
ischemic retinal injury consists of a self-reinforcing destructive cascade involving neuronal …

Shape coexistence in nuclei appears to be unique in the realm of finite many-body quantum
systems. It differs from the various geometrical arrangements that sometimes occur in a …

Mast cells are immune cells of the myeloid lineage and are present in connective tissues
throughout the body. The activation and degranulation of mast cells significantly modulates …

The complete inability to sense pain in an otherwise healthy individual is a very rare phenotype.
In three consanguineous families from northern Pakistan, we mapped the condition as …

A two-dimensional classification grid based on chemical and petrologic subdivisions of the
chondritic meteorites is proposed. This grid extends the current chemical subdivisions to …

Metformin is considered to be one of the most effective therapeutics for treating type 2
diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin …

Protein kinases have proved to be largely resistant to the design of highly specific inhibitors,
even with the aid of combinatorial chemistry 1 . The lack of these reagents has complicated …

DORSAL root ganglion sensory neurons associated with C-fibres, many of which are activated
by tissue-damage, express an unusual voltage-gated sodium channel that is resistant to …

ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation
when released from damaged tissue 1-10 . Here we report the molecular cloning and …

Measurements of hepatic iron concentration (HIC) are important predictors of transfusional
iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal …