User profiles for K. A. Youker

Keith A. Youker

Research Scientist at Houston Methodist Research Hospital
Verified email at HoustonMethodist.org
Cited by 12793

Resident cardiac mast cells degranulate and release preformed TNF-α, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion

…, ML Lindsey, LH Michael, KA Youker… - Circulation, 1998 - Am Heart Assoc
Background—Neutrophil-induced cardiomyocyte injury requires the expression of myocyte
intercellular adhesion molecule (ICAM)-1 and ICAM-1–CD11b/CD18 adhesion. We have …

Myocardial ischemia and reperfusion: a murine model

…, ML Entman, CJ Hartley, KA Youker… - American Journal …, 1995 - journals.physiology.org
Myocardial ischemia followed by reperfusion promotes a complex series of inflammatory
reactions as noted in a variety of large animal studies. With development of genetically altered …

Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions

M Gwechenberger, LH Mendoza, KA Youker… - Circulation, 1999 - Am Heart Assoc
Background—Previous work from our laboratory demonstrated that interleukin (IL)-6 plays a
potentially critical role in postreperfusion myocardial injury and is the major cytokine …

Induction of interleukin-6 synthesis in the myocardium: potential role in postreperfusion inflammatory injury

GL Kukielka, CW Smith, AM Manning, KA Youker… - Circulation, 1995 - Am Heart Assoc
Background Neutrophil-induced injury of myocardial cells requires the expression of
intercellular adhesion molecule-1 (ICAM-1) on the myocyte surface and is mediated by ICAM-1–…

Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support

SJ Matkovich, DJ Van Booven, KA Youker… - Circulation, 2009 - Am Heart Assoc
Background— Much has been learned about transcriptional control of cardiac gene
expression in clinical and experimental congestive heart failure (CHF), but less is known about …

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

H Oh, GE Taffet, KA Youker… - Proceedings of the …, 2001 - National Acad Sciences
Cardiac muscle regeneration after injury is limited by “irreversible” cell cycle exit. Telomere
shortening is one postulated basis for replicative senescence, via down-regulation of …

Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart

…, B Leighton, S Abbasi, S Patil, KA Youker… - Diabetes, 2002 - Am Diabetes Assoc
We investigated whether decreased responsiveness of the heart to physiological increases
in fatty acid availability results in lipid accumulation and lipotoxic heart disease. Lean and …

Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo.

…, TJ Daly, BJ Hughes, KA Youker… - The Journal of …, 2021 - Am Soc Clin Investig
Neutrophil adhesion and direct cytotoxicity for cardiac myocytes require chemotactic stimulation
and are dependent upon CD18-ICAM-1 binding. To characterize the potential role of IL-…

Cytokines and the microcirculation in ischemia and reperfusion

NG Frangogiannis, KA Youker, RD Rossen… - Journal of molecular and …, 1998 - Elsevier
… -1, interleukin 6 was found to be the most potent (Youker … be completely blocked by neutralizing
antibodies to IL-6 (Youker … its surface and this reaction is almost complete by 5 h (Youker

Complement C5a, TGF-β1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after …

HH Birdsall, DM Green, JA Trial, KA Youker, AR Burns… - Circulation, 1997 - Am Heart Assoc
Background Recent studies suggest that reperfusion promotes healing of formerly ischemic
heart tissue even when myocardial salvage is no longer possible. Since monocyte-…