INTRODUCTION Genetic suppression occurs when the phenotypic defects caused by a
mutated gene are rescued by a mutation in another gene. These genetic interactions can …

Chemical-genetic approaches offer the potential for unbiased functional annotation of
chemical libraries. Mutations can alter the response of cells in the presence of a compound, …

Dosage suppression is a genetic interaction in which overproduction of one gene rescues a
mutant phenotype of another gene. Although dosage suppression is known to map …

Chemical-genomic (CG) profiling of bioactive compounds is a powerful approach for drug
target identification and mode of action studies. Within the last decade, research focused …

Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by
laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is …

The core feature of trusts—holding property for the benefit of others—is well suited to
constructing a research community that treats reagents as public goods.

Natural compounds have been largely excluded from characterization via high-throughput
profiling strategies due to their limited abundance. Herein, I describe the modification of high-…

The article describes problems that cannot always be solved by machine learning algorithms
to get an accurate result. For such tasks, you need to use ensembles that actually combine …

Stress-associated p38 and JNK mitogen-activated protein (MAP) kinase signaling cascades
trigger specific cellular responses and are involved in multiple disease states. At the root of …

Dentatorubropallidoluysian atrophy (DRPLA) is one of eight autosomal dominant neurodegenerative
disorders characterized by an abnormal CAG repeat expansion which results in the …