… However, by using vertebrate opsins, we could repetitively activate K+ conductances in
HEK293 cells and modulate neuronal activity in brain slices and in vivo without a decline in …

Serotonin 2c receptors (5-HT 2c -Rs) are drug targets for certain mental disorders, including
schizophrenia, depression, and anxiety. 5-HT 2c -Rs are expressed throughout the brain, …

… Spoida et al. compare the biophysical properties and optogenetic use of mouse and human
melanopsin variants. Their findings reveal that hOpn4L and mOpn4L are new optogenetic …

Controlling gain of cortical activity is essential to modulate weights between internal ongoing
communication and external sensory drive. Here, we show that serotonergic input has …

… of the G i/o pathway by vRh induces the activation of K + conductances, such as GIRK,
which results in the efflux of K + and the hyperpolarization of the cell membrane. The bottom …

Serotonin 2C receptors (5-HT2CRs) are widely distributed throughout the brain and are
strongly implicated in the pathophysiology of anxiety disorders such as post-traumatic stress …

The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors
(5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular …

The flashlight fish Photoblepharon steinitzi inhabit coral reef caves in the Red Sea. During
the night they dwell alone or in pairs near their cave entrance, characteristic of territorial like …

The primary goal of optogenetics is the light‐controlled noninvasive and specific manipulation
of various cellular processes. Herein, we present a hybrid strategy for targeted protein …

Optogenetics combines the use of light-sensitive proteins with genetic targeting strategies.
In recent years, the expanded optogenetic toolbox has broadened the understanding of cell …