Field-deployable viral diagnostics using CRISPR-Cas13

…, AF Durbin, MJ Kellner, AL Tan, LM Paul, LA Parham… - Science, 2018 - science.org
Mitigating global infectious disease requires diagnostic tools that are sensitive, specific, and
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK (…

Zika virus evolution and spread in the Americas

…, EW Kopp, JJ Anzinger, KF Garcia, LA Parham… - Nature, 2017 - nature.com
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …

[HTML][HTML] Capturing sequence diversity in metagenomes with comprehensive and scalable probe design

…, LM Paul, AL Tan, KF Garcia, LA Parham… - Nature …, 2019 - nature.com
Metagenomic sequencing has the potential to transform microbial detection and
characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a …

Effect of resonant magnetic perturbations on COMPASS-C tokamak discharges

…, J Hugill, IJ Jenkins, RJ La Haye, BJ Parham… - Nuclear …, 1992 - iopscience.iop.org
Experimental results from the COMPASS-C tokamak reveal a sharp threshold in amplitude
above which externally applied static resonant magnetic perturbations (RMPs) induce …

Cryogenic thermonuclear fuel implosions on the National Ignition Facility

…, RE Olson, CD Orth, AE Pak, PK Patel, T Parham… - Physics of …, 2012 - pubs.aip.org
The first inertial confinement fusion implosion experiments with equimolar deuterium-tritium
thermonuclear fuel have been performed on the National Ignition Facility. These …

Progress towards ignition on the National Ignition Facility

…, DH Munro, A Nikroo, RE Olson, T Parham… - Nuclear …, 2011 - iopscience.iop.org
The National Ignition Facility at Lawrence Livermore National Laboratory was formally
dedicated in May 2009. The hohlraum energetics campaign with all 192 beams began shortly …

Capturing diverse microbial sequence with comprehensive and scalable probe design

…, YR Vieira, LM Paul, AL Tan, KF Garcia, LA Parham… - BioRxiv, 2018 - biorxiv.org
Metagenomic sequencing has the potential to transform microbial detection and
characterization, but new tools are needed to improve its sensitivity. We developed CATCH (Compact …

[HTML][HTML] Microsurgery in the burn population–a review of the literature

…, JG Goverman, KA Sarhane, CS Parham… - Annals of Burns and …, 2015 - ncbi.nlm.nih.gov
… Cet article de revue discute les indications, les applications, et des problèmes avec la
aussi la littérature disponible sur la microchirurgie du transfert de tissu libre pour la prise en …

Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules

P Parham, PJ Norman… - … Transactions of the …, 2012 - royalsocietypublishing.org
In placental mammals, natural killer (NK) cells are a population of lymphocytes that make
unique contributions to immune defence and reproduction, functions essential for survival of …

[HTML][HTML] Two to tango: co-evolution of hominid natural killer cell receptors and MHC

EE Wroblewski, P Parham, LA Guethlein - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells have diverse roles in hominid immunity and reproduction. Modulating
these functions are the interactions between major histocompatibility complex (MHC) class …