… . We expect that this method will work for larger virus genomes, but we have not tested
this protocol with viral genomes longer than 12 kb. The protocol is designed for infections …

Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast
Brazil 1 . Brazil has had the highest number of reported ZIKV cases worldwide (more than …

Serological evidence of hepatitis E virus infection (HEV) has been observed in both humans
and different animal species living in non-endemic areas, suggesting that animals could be …

Vigorous proliferative CD4 + T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

T cell exhaustion is associated with failure to clear chronic infections and malignant cells.
Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to …

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on
hepatitis C virus (HCV)-specific CD8 + and CD4 + T cells from blood and liver during acute …

Objective Chronic HBV infection affects more than 250 million people worldwide and remains
a global healthcare problem in part because we lack curative treatment. Sustained viral …

Data reported during recent years reveal the complex picture of the epidemiology of hepatitis
E virus (HEV) infection in Latin America. Whereas in countries like Argentina and Brazil is …

CD8 + -T-cell responses play an important role in the containment and clearance of hepatitis
C virus (HCV) infection, and an association between viral persistence and development of …

A vigorous hepatitis C virus (HCV)-specific Th cell response is regarded as essential to the
immunological control of HCV viremia. The aim of this study was to comprehensively define …