Nuclear shape and architecture influence gene localization, mechanotransduction, transcription,
and cell function. Abnormal nuclear morphology and protrusions termed “blebs” are …

Background. Studies of Clostridium difficile outbreaks suggested that certain ribotypes (eg,
027 and 078) cause more severe disease than other ribotypes. A growing number of studies …

The nucleus houses, organizes, and protects chromatin to ensure genome integrity and
proper gene expression, but how the nucleus adapts mechanically to changes in the …

Background B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional
genomic architecture. However, identifying the direct roles of B-lamins on …

Chemical fixation is nearly indispensable in the biological sciences, especially in circumstances
where cryo-fixation is not applicable. While universally employed for the preservation of …

Most of what we know about gene transcription comes from the view of cells as molecular
machines: focusing on the role of molecular modifications to the proteins carrying out …

Visualizing the nanoscale intracellular structures formed by nucleic acids, such as chromatin,
in nonperturbed, structurally and dynamically complex cellular systems, will help expand …

Extending across multiple length scales, dynamic chromatin structure is linked to transcription
through the regulation of genome organization. However, no individual technique can fully …

The organization of chromatin is a regulator of molecular processes including transcription,
replication, and DNA repair. The structures within chromatin that regulate these processes …

Many human diseases result from the dysregulation of the complex interactions between
tens to thousands of genes. However, approaches for the transcriptional modulation of many …