One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell
division machinery. From a reconstitution perspective, the animal cell division apparatus is …

Phylogenetic trees seem to be finding ever broader applications, and researchers from very
different backgrounds are becoming interested in what they might have to say. This tutorial …

Abstract: Our understanding of eukaryote biology is dominated by the study of land plants,
animals and fungi. However, these are only three isolated fragments of the full diversity of …

Cytoskeletal networks of actin filaments and myosin motors drive many dynamic cell processes.
A key characteristic of these networks is their contractility. Despite intense experimental …

Capturing rare yet pivotal events poses a significant challenge for molecular simulations.
Path sampling provides a unique approach to tackle this issue without altering the potential …

Molecular catch bonds are ubiquitous in biology and essential for processes like leucocyte
extravasion 1 and cellular mechanosensing 2 . Unlike normal (slip) bonds, catch bonds …

Responsive genes for fish embryos have been identified so far for some endocrine
pathways but not for androgens. Using transcriptome analysis and multiple concentration–response …

In Parkinson's disease (PD), the second most common neurodegenerative disorder, non-motor
symptoms often precede the development of debilitating motor symptoms and present a …

The cytoskeletal protein actin polymerizes into filaments that are essential for the mechanical
stability of mammalian cells. In vitro experiments showed that direct interactions between …

Current understanding of the higher order systematics of eukaryotes relies largely on analyses
of the small ribosomal subunit RNA (SSU rRNA). Independent testing of these results is …