Photodynamic therapy (PDT) has emerged as one of the important therapeutic options in
management of cancer and other diseases [M. Triesscheijn, P. Baas, JH Schellens, FA Stewart, …

The potential to harness the potency and specificity of the immune system underlies the
growing interest in cancer immunotherapy. One such approach uses bone marrow–derived …

Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is ascribed
to CD8 + T cell function, pre-clinical and clinical studies have identified intra-tumoral CD4 …

While mutations affecting protein-coding regions have been examined across many cancers,
structural variants at the genome-wide level are still poorly defined. Through integrative …

Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand
1 (PD-L1) pathway can induce robust and durable responses in patients with various …

Background Patients with advanced urothelial carcinoma that progresses after platinum-based
chemotherapy have a poor prognosis and limited treatment options. Methods In this open-…

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole-genome …

Previous studies in this laboratory established that low density lipoprotein (LDL) incubated
with cultured endothelial cells, smooth muscle cells, or macrophages undergoes free radical-…

Most tumor-associated antigens represent self-proteins and as a result are poorly immunogenic
due to immune tolerance. Here we show that tolerance to carcinoembryonic antigen (…

We identified circulating CD8+ T-cell populations specific for the tumor-associated antigens (TAAs)
MART-1 (27-35) or tyrosinase (368-376) in six of eleven patients with metastatic …