Multi-omics data integration is one of the major challenges in the era of precision medicine.
Considerable work has been done with the advent of high-throughput studies, which have …

The concept that preeclampsia is a multisystemic syndrome is appreciated in both research
and clinical care. Our understanding of pathophysiology recognizes the role of inflammation, …

Omics data contain signals from the molecular, physical, and kinetic inter- and intracellular
interactions that control biological systems. Matrix factorization (MF) techniques can reveal …

… Chaudhary, OB Poirion, and LX Garmire are listed as inventors on a provisional patent for
deep learning–based survival subpopulation prediction held by the University of Hawaii. No …

… k, l, Flow cytometric analysis and frequencies of exTh17 and Tr1 exTh17 from the lung (upper
panel: gated on CD4 + T cells; lower panel: gated on exTh17 cells). One experiment of …

Inflammation and macrophage foam cells are characteristic features of atherosclerotic
lesions, but the mechanisms linking cholesterol accumulation to inflammation and LXR-…

… Garmire’s group members for helpful discussion on this project. … Huang S, Chong N,
Lewis NE, Jia W, Xie G, Garmire LX. Novel personalized pathway-based metabolomics models …

It is crucial for researchers to optimize RNA-seq experimental designs for differential expression
detection. Currently, the field lacks general methods to estimate power and sample size …

Single-cell RNA sequencing (scRNA-seq) offers new opportunities to study gene expression
of tens of thousands of single cells simultaneously. We present DeepImpute, a deep neural …

… RNAse L was shown to suppress prostate tumorigenesis by initiating a cellular stress
response that leads to cancer cell apoptosis 58,59 . Tumors, on the other hand, reportedly display …