[PDF][PDF] Tension-dependent stretching activates ZO-1 to control the junctional localization of its interactors
Tensile forces regulate epithelial homeostasis, but the molecular mechanisms behind this
regulation are poorly understood. Using structured illumination microscopy and proximity …
regulation are poorly understood. Using structured illumination microscopy and proximity …
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
L Guillemot, S Paschoud, L Jond… - Molecular biology of the …, 2008 - Am Soc Cell Biol
Small GTPases control key cellular events, including formation of cell–cell junctions and gene
expression, and are regulated by activating and inhibiting factors. Here, we characterize …
expression, and are regulated by activating and inhibiting factors. Here, we characterize …
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal …
…, D Pizzuti, D Martines, L Jond… - Journal of cell …, 2012 - journals.biologists.com
Cingulin (CGN) is a 140 kDa protein, which is localized to the cytoplasmic region of vertebrate
tight junctions (TJ), and regulates gene expression and RhoA signaling in cultured cells. …
tight junctions (TJ), and regulates gene expression and RhoA signaling in cultured cells. …
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression
…, C Kaister, J Ritz, D Caille, L Jond… - Journal of cell …, 2004 - journals.biologists.com
Cingulin, a component of vertebrate tight junctions, contains a head domain that controls its
junctional recruitment and protein interactions. To determine whether lack of junctional …
junctional recruitment and protein interactions. To determine whether lack of junctional …
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly
…, D Guerrera, D Spadaro, R Tapia, L Jond… - Molecular biology of …, 2014 - Am Soc Cell Biol
The regulation of Rho-family GTPases is crucial to direct the formation of cell–cell junctions
and tissue barriers. Cingulin (CGN) and paracingulin (CGNL1) control RhoA activation in …
and tissue barriers. Cingulin (CGN) and paracingulin (CGNL1) control RhoA activation in …
[HTML][HTML] ZO proteins redundantly regulate the transcription factor DbpA/ZONAB
D Spadaro, R Tapia, L Jond, M Sudol… - Journal of Biological …, 2014 - ASBMB
The localization and activities of DbpA/ZONAB and YAP transcription factors are in part
regulated by the density-dependent assembly of epithelial junctions. DbpA activity and cell …
regulated by the density-dependent assembly of epithelial junctions. DbpA activity and cell …
[HTML][HTML] Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation
… L, densitometric quantification of binding of CGN preys to the GST-hZO-1-CterL bait (IB in
[K]). M–O, scheme of CGNL1 prey and ZO-1 bait constructs (M) and IB analysis (N) and …
[K]). M–O, scheme of CGNL1 prey and ZO-1 bait constructs (M) and IB analysis (N) and …
PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis
…, T Xiao, A Boukhatemi, F Ferreira, L Jond… - Molecular biology of …, 2021 - Am Soc Cell Biol
Copper homeostasis is crucial for cellular physiology and development, and its dysregulation
leads to disease. The Menkes ATPase ATP7A plays a key role in copper efflux, by …
leads to disease. The Menkes ATPase ATP7A plays a key role in copper efflux, by …
The tight junction protein cingulin regulates gene expression and RhoA signaling
…, F De Robertis, L Jond, L Guillemot - Annals of the New …, 2009 - Wiley Online Library
Tight junctions (TJ) regulate the passage of solutes across epithelial sheets, contribute to
the establishment and maintenance of epithelial apico‐basal polarity and are involved in the …
the establishment and maintenance of epithelial apico‐basal polarity and are involved in the …
PLEKHA7 modulates epithelial tight junction barrier function
S Paschoud, L Jond, D Guerrera, S Citi - Tissue barriers, 2014 - Taylor & Francis
PLEKHA7 is a recently identified protein of the epithelial zonula adhaerens (ZA), and is part
of a protein complex that stabilizes the ZA, by linking it to microtubules. Since the ZA is …
of a protein complex that stabilizes the ZA, by linking it to microtubules. Since the ZA is …