Eukaryotic cells are partitioned into functionally distinct self-organizing compartments. But
while the biogenesis of membrane-surrounded compartments is beginning to be understood, …

Proteins regulate biological processes by changing their structure or abundance to accomplish
a specific function. In response to a perturbation, protein structure may be altered by …

Hydrotropes are small molecules that solubilize hydrophobic molecules in aqueous solutions.
Typically, hydrotropes are amphiphilic molecules and differ from classical surfactants in …

10.7554/eLife.06807.001 RNA-protein (RNP) granules have been proposed to assemble by
forming solid RNA/protein aggregates or through phase separation into a liquid RNA/…

10.7554/eLife.09347.001 Cells can enter into a dormant state when faced with unfavorable
conditions. However, how cells enter into and recover from this state is still poorly understood…

10.7554/eLife.02409.001 One of the key questions in biology is how the metabolism of a
cell responds to changes in the environment. In budding yeast, starvation causes a drop in …

Acute stress causes a rapid redistribution of protein quality control components and
aggregation-prone proteins to diverse subcellular compartments. How these remarkable changes …

Biological processes are regulated by intermolecular interactions and chemical modifications
that do not affect protein levels, thus escaping detection in classical proteomic screens. We …

Background Many unicellular organisms age: as time passes, they divide more slowly and
ultimately die. In budding yeast, asymmetric segregation of cellular damage results in aging …

… Some inhibition effects are shown by the monosaccharides of the L-galacto series, such
as L-fucose, D-arabinose and L-galactose, but are two orders of magnitude weaker than D-…