This study describes comprehensive polling of transcription start and termination sites and
analysis of previously unidentified full-length complementary DNAs derived from the mouse …

With the world population aging and the number of healthcare users with multiple chronic
diseases increasing, healthcare is becoming more costly, and as such, the need to optimise …

Background: Three gene expression–based prognostic breast cancer tests have been licensed
for use. Purpose: To summarize evidence on the validity and utility of 3 gene expression–…

Traditional approaches to the preclinical investigation of cancer therapies rely on the use of
established cell lines maintained in serum-based growth media. This is particularly true of …

… have different base pair lengths l 1 , l 2 , …, l n . It is also possible to include the effects of
differing nucleotide compositions by multiplying the various l values by a factor depending on …

Background Radical prostatectomy (RP) is a primary treatment option for men with intermediate-
and high-risk prostate cancer. Although many are effectively cured with local therapy …

Medical artificial intelligence (AI) has tremendous potential to advance healthcare by
supporting and contributing to the evidence-based practice of medicine, personalizing patient …

Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC),
with clinical and biological implications. Lineage-dependent stromal transcriptional …

Human induced pluripotent stem cells (iPSCs) are a potential source of hepatocytes for liver
transplantation to treat end-stage liver disease. In vitro differentiation of human iPSCs into …

A majority of cancers fail to respond to immunotherapy with antibodies targeting immune
checkpoints, such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) or programmed death-1 (PD-1)…