[HTML][HTML] Sex differences of microglia and synapses in the hippocampal dentate gyrus of adult mouse offspring exposed to maternal immune activation
Schizophrenia is a psychiatric disorder affecting ∼1% of humans worldwide. It is earlier and
more frequently diagnosed in men than woman, and men display more pronounced …
more frequently diagnosed in men than woman, and men display more pronounced …
Semaphorin4D induces inhibitory synapse formation by rapid stabilization of presynaptic boutons via MET coactivation
CP Frias, J Liang, T Bresser, L Scheefhals… - Journal of …, 2019 - Soc Neuroscience
Changes in inhibitory connections are essential for experience-dependent circuit adaptations.
Defects in inhibitory synapses are linked to neurodevelopmental disorders, but the …
Defects in inhibitory synapses are linked to neurodevelopmental disorders, but the …
Dose-dependent kinetics of aminopyrine metabolism in the rat caused by product inhibition and determined by capillary GLC
A Bast, LWC Scheefhals, J Noordhoek - Pharmacology, 1982 - karger.com
Aminopyrine (DMAP) and its metabolites were estimated in plasma and urine with a newly
developed capillary GLC method, using nitrogen detection. Dose-dependent kinetics for …
developed capillary GLC method, using nitrogen detection. Dose-dependent kinetics for …
Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat
…, FAA van Kemenade, LWC Scheefhals… - Archives of …, 1983 - Springer
Multiple administration (ip) of orphenadrine or its mono-N-de-methylated metabolite, tofenacine
(day 1, 20 mg/kg; day 2–5, 30 mg/kg) results in a considerable induction (50%) of the …
(day 1, 20 mg/kg; day 2–5, 30 mg/kg) results in a considerable induction (50%) of the …
Semaphorin4D induces inhibitory synapse formation by rapid stabilization of presynaptic boutons via MET co-activation
CP Frias, T Bresser, L Scheefhals, H Yin Hu… - bioRxiv, 2017 - biorxiv.org
ABSTRACT Changes in inhibitory connections are essential for experience-dependent circuit
adaptations. Defects in inhibitory synapses are linked to neurodevelopmental disorders, …
adaptations. Defects in inhibitory synapses are linked to neurodevelopmental disorders, …
Occupational exposure to antineoplastic agents at several departments in a hospital: environmental contamination and excretion of cyclophosphamide and ifosfamide …
PJM Sessink, KA Boer, APH Scheefhals… - International archives of …, 1992 - Springer
… l 13 l We describe the occupational exposure of 25 hospital workers involved in handling
antineoplastic agents at four departments in which CP, IF, 5 FU, and MTX were prepared or …
antineoplastic agents at four departments in which CP, IF, 5 FU, and MTX were prepared or …
[HTML][HTML] Microglia innately develop within cerebral organoids
…, LE Johansen, RE van Dijk, N Scheefhals… - Nature …, 2018 - nature.com
Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human
brain. The current consensus is that cerebral organoids consist of cells derived from the …
brain. The current consensus is that cerebral organoids consist of cells derived from the …
[PDF][PDF] Shank proteins couple the endocytic zone to the postsynaptic density to control trafficking and signaling of metabotropic glutamate receptor 5
N Scheefhals, LAE Catsburg, ML Westerveld… - Cell reports, 2019 - cell.com
Activation of postsynaptic metabotropic glutamate receptors (mGluRs) modulates neuronal
excitability and synaptic plasticity, while deregulation of mGluR signaling has been …
excitability and synaptic plasticity, while deregulation of mGluR signaling has been …
[HTML][HTML] ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons
J Willems, APH de Jong, N Scheefhals, E Mertens… - PLoS …, 2020 - journals.plos.org
The correct subcellular distribution of proteins establishes the complex morphology and
function of neurons. Fluorescence microscopy techniques are invaluable to investigate …
function of neurons. Fluorescence microscopy techniques are invaluable to investigate …
[HTML][HTML] mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function
N Scheefhals, M Westra, HD MacGillavry - Nature communications, 2023 - nature.com
… We therefore estimated the confinement index L, which relates to the probability that a molecule
… Using a critical threshold of confinement L c we defined regions of confined diffusion, or …
… Using a critical threshold of confinement L c we defined regions of confined diffusion, or …