The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 , 2 , 3
– 4 . Here we present analyses of driver point mutations and structural variants in non-…

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation, …

Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic
options. The mechanisms underlying LMS development, including clinically actionable genetic …

Chromothripsis is a recently identified mutational phenomenon, by which a presumably
single catastrophic event generates extensive genomic rearrangements of one or a few …

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

Food refusal is a severe feeding problem in which children refuse to eat all or most foods
presented and exhibit problems with growth. This review discusses the definition, etiology, and …

Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International
Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome …

Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT)
is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in …

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They
achieve this through TERT activation or alternative telomere lengthening associated with …

Studying the interplay between nonribosomal peptide synthetases (NRPS), a major source of
secondary metabolites, and crucial external modifying enzymes is a challenging task since …