The postsynaptic density (PSD) of central excitatory synapses is essential for postsynaptic
signaling, and its components are heterogeneous among different neuronal subtypes and …

Synaptic cargo trafficking is essential for synapse formation, function and plasticity. In order
to transport synaptic cargo, such as synaptic vesicle precursors, mitochondria, …

Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report
the structure of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 angstroms…

In neurons, the distinct molecular composition of axons and dendrites is established through
polarized targeting mechanisms, but it is currently unclear how nonpolarized cargoes, such …

Cytoplasmic dynein is an approximately 1.4 MDa multi‐protein complex that transports
many cellular cargoes towards the minus ends of microtubules. Several in vitro studies of …

BACKGROUND: To establish and maintain their polarized morphology, neurons employ
active transport driven by molecular motors to sort cargo between axons and dendrites. …

Cytoplasmic dynein is the major microtubule minus-end–directed cellular motor. Most
dynein activities require dynactin, but the mechanisms regulating cargo-dependent dynein–…

Kinesin and dynein motors transport intracellular cargos bidirectionally by pulling them in
opposite directions along microtubules, through a process frequently described as a ‘tug of war…

Although purified cytoskeletal motor proteins have been studied extensively with the use of
in vitro approaches, a generic approach to selectively probe actin and microtubule-based …

Membrane and secretory trafficking are essential for proper neuronal development. However,
the molecular mechanisms that organize secretory trafficking are poorly understood. Here, …