User profiles for M. B. Kennedy

Mary B. Kennedy

Allen and Lenabelle Davis Professor of Biology, California Institute of Technology
Verified email at its.caltech.edu
Cited by 21335

Signal-processing machines at the postsynaptic density

MB Kennedy - Science, 2000 - science.org
Dendrites of individual neurons in the vertebrate central nervous system are contacted by
thousands of synaptic terminals relaying information about the environment. The postsynaptic …

The postsynaptic density at glutamatergic synapses

MB Kennedy - Trends in neurosciences, 1997 - cell.com
The postsynaptic density (PSD) is a tiny, amorphous structure located beneath the
postsynaptic membrane of synapses in the CNS. Until recently, the molecular composition and …

Interaction of ion channels and receptors with PDZ domain proteins

HC Kornau, PH Seeburg, MB Kennedy - Current opinion in neurobiology, 1997 - Elsevier
The complex anatomy of neurons demands a high degree of functional organization. Therefore,
membrane receptors and ion channels are often localized to selected subcellular sites …

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

HC Kornau, LT Schenker, MB Kennedy, PH Seeburg - Science, 1995 - science.org
The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission
and plasticity in central neurons. The yeast two-hybrid system was used to show that …

Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and …

…, L Wilming, MS Tassinari, MB Kennedy… - Journal of cellular …, 1990 - Wiley Online Library
The relationship of cell proliferation to the temporal expression of genes characterizing a
developmental sequence associated with bone cell differentiation was examined in primary …

The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein

KO Cho, CA Hunt, MB Kennedy - Neuron, 1992 - cell.com
… densities as well as in the dendritic shaft (Kennedy et al., 1983, 1990; Ouimet et al., 1984). …
the ct subunit of CaM kinase II (Erondu and Kennedy, 1985). The antibodies were diluted in Tri…

Regulation of brain Type II Ca2+ calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

SG Miller, MB Kennedy - Cell, 1986 - cell.com
… It also appears to be concentrated in postsynaptic densities (submembranous cytoskeletal
structures that occur at many postsynaptic sites in the central nervous system [Kennedy et al., …

Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain

NE Erondu, MB Kennedy - Journal of Neuroscience, 1985 - Soc Neuroscience
… DeLorenzo and MB Kennedy, unpublished observations). These findings, the association
of the kinase with the postsynaptic density fraction, and its association with the cytoskeleton in …

[PDF][PDF] A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II

HJ Chen, M Rojas-Soto, A Oguni, MB Kennedy - Neuron, 1998 - cell.com
… concentrated in a complex of proteins known as the postsynaptic density (PSD) (Kennedy
et … Asterisks indicate the positions of previously identified proteins (Kennedy, 1997). Ar…

Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain.

MK Bennett, NE Erondu, MB Kennedy - Journal of Biological Chemistry, 1983 - ASBMB
… Purification of Calmodulin-dependent Synapsin I Kinase The initial steps of the purification
(through calmodulin affinity chromatography) were as previously described by Kennedy et al. (…