Thrombotic complications of vascular disease are the leading cause of morbidity and
mortality in most industrialized countries. Despite this, safe and effective drugs targeting these …

Breast cancer is a complex and heterogeneous disease. Signaling by estrogen receptor (ER),
progesterone receptor (PR), and/or human EGF-like receptor 2 (HER2) is a main driver in …

To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor
therapy response, we performed DNA and RNA sequencing on GBM samples and the …

Autism is a highly heritable neurodevelopmental disorder, yet the genetic underpinnings of
the disorder are largely unknown. Aberrant brain overgrowth is a well-replicated observation …

Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of
benign tumours and other hamartomatous lesions, which leads to diverse and debilitating …

… When resident physicians come to me after admitting a patient to the hospital for a heart
attack and then proceed to tell me the patients risk factors for heart disease indicate the patient …

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species
including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (…

We hypothesize that granulosa and theca cells from growing dominant follicles, with
relatively high intrafollicular concentrations of estradiol, have a greater expression of genes …

Mutations affecting components of the mitochondrial electron transport chain have been
shown to increase lifespan in multiple species including the worm Caenorhabditis elegans. …

Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion,
yet there are few therapeutic options to protect cognitive function following cerebrovascular …