An 11.7‐Å‐resolution cryo‐EM map of the yeast 80S·eEF2 complex in the presence of the
antibiotic sordarin was interpreted in molecular terms, revealing large conformational changes …

The Plasmodium liver stage represents a vulnerable therapeutic target to prevent disease
progression as the parasite resides in the liver before clinical representation caused by …

Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …

Microbial resistance to chemotherapy has caused countless deaths where malaria is
endemic. Chemotherapy may fail either due to pre-existing resistance or evolution of drug-resistant …

… Thirty microliters of 13.73 μM Ile or 1.373 mM Val and yeast tRNA (0.48 mg/ml) in assay buffer
(… The peak fractions containing purified PvcIRS were pooled and concentrated to 3.0 mg/ml …

Using a sordarin derivative, an antifungal drug, it was possible to determine the structure of
a eukaryotic ribosome· EF2 complex at 17.5 Å resolution by three-dimensional (3D) cryo-…

Sordarin derivatives are selective inhibitors of fungal protein synthesis, which specifically
impair elongation factor 2 (EF-2) function. We have studied the effect of sordarin on the …

Background The emergence of Plasmodium falciparum resistance to artemisinins threatens
to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. …

Widespread Plasmodium falciparum resistance to first-line antimalarials underscores the vital
need to develop compounds with novel modes of action and identify new druggable targets…

In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets,
however, key obstacles to eliciting resistance are the parasite inoculum size and mutation …