… Melissa Little, Minoru Takasato and colleagues showed previously that human pluripotent
stem cells (hPSCs) can differentiate into both types of progenitors. They have now identified …

In late 2004, an International Consortium of research groups were charged with the task of
producing a high-quality molecular anatomy of the developing mammalian urogenital tract (…

Directed differentiation of human pluripotent stem cells to kidney organoids brings the prospect
of drug screening, disease modelling and the generation of tissue for renal replacement. …

The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors—resulting …

… preparations, ABCG2 coexpression with the HSC markers CD34 and CD133 was observed
at low or undetectable levels, and cells sorted solely for the marker ABCG2 had little colony-…

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

… Few definitive markers identify these plastic-adherent mesenchymal cells, and in most
studies, there is little definitive proof that these cells are true “stem cells.” Hence, it has been …

With the prevalence of end-stage renal disease rising 8% per annum globally 1 , there is an
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …

… However, the differentiation protocol used in that study contained predominantly nascent
glomeruli and little proximal tubular structures. In contrast, the protocol of Takasato et al. (2015) …

While nephron formation is known to be initiated by a mesenchyme-to-epithelial transition of
the cap mesenchyme to form a renal vesicle (RV), the subsequent patterning of the nephron …