Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
…, TW Giessen, M Baym, SJ Kerns, MJ Niederhuber… - Nature …, 2017 - nature.com
Bacteria can be engineered to function as diagnostics or therapeutics in the mammalian gut
but commercial translation of technologies to accomplish this has been hindered by the …
but commercial translation of technologies to accomplish this has been hindered by the …
Hormone-dependent control of developmental timing through regulation of chromatin accessibility
CM Uyehara, SL Nystrom, MJ Niederhuber… - Genes & …, 2017 - genesdev.cshlp.org
Specification of tissue identity during development requires precise coordination of gene
expression in both space and time. Spatially, master regulatory transcription factors are …
expression in both space and time. Spatially, master regulatory transcription factors are …
Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development
SL Nystrom, MJ Niederhuber, DJ McKay - Development, 2020 - journals.biologists.com
How temporal cues combine with spatial inputs to control gene expression during development
is poorly understood. Here, we test the hypothesis that the Drosophila transcription factor …
is poorly understood. Here, we test the hypothesis that the Drosophila transcription factor …
Synthetic gene circuits enable systems-level biosensor trigger discovery at the host-microbe interface
…, D Trivedi, N Nissar, MC Inniss, MJ Niederhuber… - …, 2019 - Am Soc Microbiol
Engineering synthetic circuits into intestinal bacteria to sense, record, and respond to in vivo
signals is a promising new approach for the diagnosis, treatment, and prevention of disease…
signals is a promising new approach for the diagnosis, treatment, and prevention of disease…
[PDF][PDF] Mechanisms underlying the control of dynamic regulatory element activity and chromatin accessibility during metamorphosis
MJ Niederhuber, DJ McKay - Current opinion in insect science, 2021 - Elsevier
FAIRE relies on inherent differences between histones and transcription factors to be
crosslinked to DNA by formaldehyde. After a brief fixation, the sample is sonicated and open …
crosslinked to DNA by formaldehyde. After a brief fixation, the sample is sonicated and open …
Superresolution microscopy of the β-carboxysome reveals a homogeneous matrix
MJ Niederhuber, TJ Lambert, C Yapp… - Molecular biology of …, 2017 - Am Soc Cell Biol
Carbon fixation in cyanobacteria makes a major contribution to the global carbon cycle. The
cyanobacterial carboxysome is a proteinaceous microcompartment that protects and …
cyanobacterial carboxysome is a proteinaceous microcompartment that protects and …
The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development
MJ Niederhuber, M Leatham-Jensen, DJ McKay - Genetics, 2024 - academic.oup.com
Chromatin remodeling is central to the dynamic changes in gene expression that drive cell
fate determination. During development, the sets of enhancers that are accessible for use …
fate determination. During development, the sets of enhancers that are accessible for use …
Long-term monitoring of inflammation in the mammalian gut using programmable commensal bacteria
Inflammation in the gut, caused by infection and autoimmunity, remains challenging to
effectively detect, monitor, and treat. Here, we engineer a commensal mouse E. coli strain to …
effectively detect, monitor, and treat. Here, we engineer a commensal mouse E. coli strain to …
Fine-Tuning Enhancer Activity in Development
MJ Niederhuber - 2023 - search.proquest.com
The development of a multicellular organism, from the origin of a single cell, depends on the
manipulation of a shared genome to generate increasingly differentiated and specialized …
manipulation of a shared genome to generate increasingly differentiated and specialized …
The temporal transcription factor E93 controls dynamic enhancer activity and chromatin accessibility during development
SL Nystrom, MJ Niederhuber, DJ McKay - bioRxiv, 2019 - biorxiv.org
How temporal cues combine with spatial inputs to control gene expression during development
is poorly understood. Here, we test the hypothesis that the Drosophila transcription factor …
is poorly understood. Here, we test the hypothesis that the Drosophila transcription factor …