Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation

…, TW Giessen, M Baym, SJ Kerns, MJ Niederhuber… - Nature …, 2017 - nature.com
Bacteria can be engineered to function as diagnostics or therapeutics in the mammalian gut
but commercial translation of technologies to accomplish this has been hindered by the …

Hormone-dependent control of developmental timing through regulation of chromatin accessibility

CM Uyehara, SL Nystrom, MJ Niederhuber… - Genes & …, 2017 - genesdev.cshlp.org
Specification of tissue identity during development requires precise coordination of gene
expression in both space and time. Spatially, master regulatory transcription factors are …

Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development

SL Nystrom, MJ Niederhuber, DJ McKay - Development, 2020 - journals.biologists.com
How temporal cues combine with spatial inputs to control gene expression during development
is poorly understood. Here, we test the hypothesis that the Drosophila transcription factor …

Synthetic gene circuits enable systems-level biosensor trigger discovery at the host-microbe interface

…, D Trivedi, N Nissar, MC Inniss, MJ Niederhuber… - …, 2019 - Am Soc Microbiol
Engineering synthetic circuits into intestinal bacteria to sense, record, and respond to in vivo
signals is a promising new approach for the diagnosis, treatment, and prevention of disease…

[PDF][PDF] Mechanisms underlying the control of dynamic regulatory element activity and chromatin accessibility during metamorphosis

MJ Niederhuber, DJ McKay - Current opinion in insect science, 2021 - Elsevier
FAIRE relies on inherent differences between histones and transcription factors to be
crosslinked to DNA by formaldehyde. After a brief fixation, the sample is sonicated and open …

Superresolution microscopy of the β-carboxysome reveals a homogeneous matrix

MJ Niederhuber, TJ Lambert, C Yapp… - Molecular biology of …, 2017 - Am Soc Cell Biol
Carbon fixation in cyanobacteria makes a major contribution to the global carbon cycle. The
cyanobacterial carboxysome is a proteinaceous microcompartment that protects and …

The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development

MJ Niederhuber, M Leatham-Jensen, DJ McKay - Genetics, 2024 - academic.oup.com
Chromatin remodeling is central to the dynamic changes in gene expression that drive cell
fate determination. During development, the sets of enhancers that are accessible for use …

Long-term monitoring of inflammation in the mammalian gut using programmable commensal bacteria

DT Riglar, M Baym, SJ Kerns, MJ Niederhuber… - BioRxiv, 2016 - biorxiv.org
Inflammation in the gut, caused by infection and autoimmunity, remains challenging to
effectively detect, monitor, and treat. Here, we engineer a commensal mouse E. coli strain to …

Fine-Tuning Enhancer Activity in Development

MJ Niederhuber - 2023 - search.proquest.com
The development of a multicellular organism, from the origin of a single cell, depends on the
manipulation of a shared genome to generate increasingly differentiated and specialized …

The temporal transcription factor E93 controls dynamic enhancer activity and chromatin accessibility during development

SL Nystrom, MJ Niederhuber, DJ McKay - bioRxiv, 2019 - biorxiv.org
How temporal cues combine with spatial inputs to control gene expression during development
is poorly understood. Here, we test the hypothesis that the Drosophila transcription factor …