User profiles for M. L. Siegal

Mark L Siegal

Professor of Biology, New York University
Verified email at nyu.edu
Cited by 5297

Robustness: mechanisms and consequences

J Masel, ML Siegal - Trends in genetics, 2009 - cell.com
Biological systems are robust to perturbation by mutations and environmental fluctuations.
New data are shedding light on the biochemical and network-level mechanisms responsible …

The details in the distributions: why and how to study phenotypic variability

…, CR Bauer, S Li, N Ziv, D Gresham, ML Siegal - Current opinion in …, 2013 - Elsevier
Highlights • Variation exists within genetically identical populations raised in nominally identical
environments. • This variation, called ‘phenotypic variability,’is relevant in medicine and …

On the nature and evolutionary impact of phenotypic robustness mechanisms

ML Siegal, JY Leu - Annual review of ecology, evolution, and …, 2014 - annualreviews.org
… as candidates for contributing to rare adaptive events that punctuate long periods of stasis
(Siegal 2013). … We thank members of the Siegal and Leu laboratories for helpful discussions. …

Waddington's canalization revisited: developmental stability and evolution

ML Siegal, A Bergman - Proceedings of the National …, 2002 - National Acad Sciences
Most species maintain abundant genetic variation and experience a range of environmental
conditions, yet phenotypic variation is low. That is, development is robust to changes in …

Evolutionary capacitance as a general feature of complex gene networks

A Bergman, ML Siegal - Nature, 2003 - nature.com
An evolutionary capacitor buffers genotypic variation under normal conditions, thereby
promoting the accumulation of hidden polymorphism. But it occasionally fails, thereby revealing …

Precise estimates of mutation rate and spectrum in yeast

YO Zhu, ML Siegal, DW Hall… - Proceedings of the …, 2014 - National Acad Sciences
… Cells in the final 288-mL liquid cultures were pelleted for DNA extraction. DNA extractions
were carried out using the Qiagen Genomic Q-Tip 100 following standard protocols. Then, 2 …

[HTML][HTML] Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant

SF Levy, N Ziv, ML Siegal - PLoS biology, 2012 - journals.plos.org
… Bud scar staining was performed for 15 min in 1 mg ml −1 TRITC-labeled WGA. All sorting
was done using a tight pulse-width gate to remove cell clumps from the analysis. For co-…

[HTML][HTML] Network hubs buffer environmental variation in Saccharomyces cerevisiae

SF Levy, ML Siegal - PLoS biology, 2008 - journals.plos.org
… A single medium-sized colony was added to 5 ml of … Cells were subsequently grown
overnight in 3 ml YEPD at 30 … Cells were counted, then 1 × 10 8 cells were added to 20 ml

Transgene Coplacement and High Efficiency Site-Specific Recombination With the Cre/loxP System in Drosophila

ML Siegal, DL Hartl - Genetics, 1996 - academic.oup.com
Studies of gene function and regulation in transgenic Drosophila are often compromised by
the possibility of genomic position effects on gene expression. We have developed a method…

Heritability and the equal environments assumption: Evidence from multiple samples of misclassified twins

…, E Rauscher, C Dawes, PKE Magnusson, ML Siegal - Behavior Genetics, 2013 - Springer
Classically derived estimates of heritability from twin models have been plagued by the
possibility of genetic-environmental covariance. Survey questions that attempt to measure …