User profiles for M. L. Siegal
Mark L SiegalProfessor of Biology, New York University Verified email at nyu.edu Cited by 5297 |
Robustness: mechanisms and consequences
Biological systems are robust to perturbation by mutations and environmental fluctuations.
New data are shedding light on the biochemical and network-level mechanisms responsible …
New data are shedding light on the biochemical and network-level mechanisms responsible …
The details in the distributions: why and how to study phenotypic variability
Highlights • Variation exists within genetically identical populations raised in nominally identical
environments. • This variation, called ‘phenotypic variability,’is relevant in medicine and …
environments. • This variation, called ‘phenotypic variability,’is relevant in medicine and …
On the nature and evolutionary impact of phenotypic robustness mechanisms
… as candidates for contributing to rare adaptive events that punctuate long periods of stasis
(Siegal 2013). … We thank members of the Siegal and Leu laboratories for helpful discussions. …
(Siegal 2013). … We thank members of the Siegal and Leu laboratories for helpful discussions. …
Waddington's canalization revisited: developmental stability and evolution
Most species maintain abundant genetic variation and experience a range of environmental
conditions, yet phenotypic variation is low. That is, development is robust to changes in …
conditions, yet phenotypic variation is low. That is, development is robust to changes in …
Evolutionary capacitance as a general feature of complex gene networks
An evolutionary capacitor buffers genotypic variation under normal conditions, thereby
promoting the accumulation of hidden polymorphism. But it occasionally fails, thereby revealing …
promoting the accumulation of hidden polymorphism. But it occasionally fails, thereby revealing …
Precise estimates of mutation rate and spectrum in yeast
… Cells in the final 288-mL liquid cultures were pelleted for DNA extraction. DNA extractions
were carried out using the Qiagen Genomic Q-Tip 100 following standard protocols. Then, 2 …
were carried out using the Qiagen Genomic Q-Tip 100 following standard protocols. Then, 2 …
[HTML][HTML] Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant
… Bud scar staining was performed for 15 min in 1 mg ml −1 TRITC-labeled WGA. All sorting
was done using a tight pulse-width gate to remove cell clumps from the analysis. For co-…
was done using a tight pulse-width gate to remove cell clumps from the analysis. For co-…
[HTML][HTML] Network hubs buffer environmental variation in Saccharomyces cerevisiae
… A single medium-sized colony was added to 5 ml of … Cells were subsequently grown
overnight in 3 ml YEPD at 30 … Cells were counted, then 1 × 10 8 cells were added to 20 ml …
overnight in 3 ml YEPD at 30 … Cells were counted, then 1 × 10 8 cells were added to 20 ml …
Transgene Coplacement and High Efficiency Site-Specific Recombination With the Cre/loxP System in Drosophila
Studies of gene function and regulation in transgenic Drosophila are often compromised by
the possibility of genomic position effects on gene expression. We have developed a method…
the possibility of genomic position effects on gene expression. We have developed a method…
Heritability and the equal environments assumption: Evidence from multiple samples of misclassified twins
Classically derived estimates of heritability from twin models have been plagued by the
possibility of genetic-environmental covariance. Survey questions that attempt to measure …
possibility of genetic-environmental covariance. Survey questions that attempt to measure …