The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-2
(HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …

Members of the human epidermal growth factor receptor (HER) family have been of considerable
interest in the cancer arena due to their potential to induce tumorigenesis when their …

Oncogenic tyrosine kinases have proved to be promising targets for the development of highly
effective anticancer drugs. However, tyrosine kinase inhibitors (TKIs) against the human …

The epidermal growth factor receptor (EGFR) is commonly overexpressed in many human
tumors and provides a new target for anticancer drug development. ZD1839 (“Iressa”), a …

Gossypol has demonstrated in vitro effects on cell cycle regulation and anti-tumor activity
against mammary carcinoma cell lines. This Phase I/II study assesses both the effect of …

Purpose: Tyrosine kinase (TK) inhibitors are emerging as a promising new approach to the
treatment of HER overexpressing tumors, however optimal use of these agents awaits further …

The year 2007 marks exactly two decades since human epidermal growth factor receptor-2 (HER2)
was functionally implicated in the pathogenesis of human breast cancer (Slamon et al…

The human epidermal growth family (HER) of tyrosine kinase receptors underlies the
pathogenesis of many types of human cancer. The oncogenic functions of three of the HER …

… When the average tumor sizes reached ~100 mm 3 , mice were randomized to three groups
of 10 mice each. One group was treated with lapatinib at 100 mg/kg per day every day for 42 …