Three-dimensional (3D) cultures are increasing in use because of their ability to represent in
vivo human physiology when compared to monolayer two-dimensional (2D) cultures. When …

Common recommendations for cell line authentication, annotation and quality control fall
short addressing genetic heterogeneity. Within the Human Toxome Project, we demonstrate …

Three-dimensional (3-D) in vitro platforms have been shown to closely recapitulate human
physiology when compared with conventional two-dimensional (2-D) in vitro or in vivo animal …

The twenty-first century vision for toxicology involves a transition away from high-dose animal
studies to in vitro and computational models (NRC in Toxicity testing in the 21st century: a …

Current human reproductive risk assessment methods rely on semen and serum hormone
analyses, which are not easily comparable to the histopathological endpoints and mating …

It is well-established that upregulation of drug efflux pumps leads to multi-drug resistance.
Less is known about the role of the architecture of the tumor microenvironment in this process: …

The development of three-dimensional (3D) cultures is increasing, as they are able to provide
the utility of in vitro models and the strength of testing in physiologically relevant systems. …

In the development of human cell-based assays, 3-dimensional (3D) cell culture models are
intriguing as they are able to bridge the gap between animal models and traditional two-…

None of the ABCG2 inhibitors are effective clinically against multidrug resistant tumors
overexpressing ABCG2. New in vitro models are needed to characterize inhibitors and discover …

The tumor suppressor protein p53 ( TP 53) has many functions in cell cycle regulation,
apoptosis, and DNA damage repair and is also involved in spermatogenesis in the mouse. To …