Despite the growing number of immune repertoire sequencing studies, the field still lacks
software for analysis and comprehension of this high-dimensional data. Here we report …

SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4 + T cell
responses. It is not yet clear whether vaccine-induced follicular helper CD4 + T (T FH ) cell …

Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high,
variant emergence has prompted booster immunizations. However, the effects of repeated …

In 2016, we started a community effort to gather and curate publicly available sequence
data acquired from T cell receptor (TCRs) with defined antigen specificities, as well as …

Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in
antigen recognition during the adaptive immune response. Recent progress in next-generation …

COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key
role in the adaptive antiviral immune response by killing infected cells and facilitating the …

The diversity, architecture, and dynamics of the TCR repertoire largely determine our ability
to effectively withstand infections and malignancies with minimal mistargeting of immune …

High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we
found that Australian First Nations peoples elicit effective immune responses to COVID-19 …

Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface
of B and T cells. The final set of these molecules in each organism is formed under the …

… Right panel shows the number of clonotypes identified by the algorithm that have high
similarity to clonotypes significantly expanded after YF immunization from Pogorelyy and …