A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling, …

Cell type specific transcriptional regulation must be adhered to in order to maintain cell
identity throughout the lifetime of an organism, yet it must be flexible enough to allow for …

Monoallelic gene expression is a remarkable process in which transcription occurs from
only one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of …

Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant
phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin …

We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres
by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs …

Mouse embryonic stem cells derived from the epiblast 1 contribute to the somatic lineages
and the germline but are excluded from the extra-embryonic tissues that are derived from the …

Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle
through a state characterized by decondensed chromatin and expression of transcripts, …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C-like” …

Random autosomal monoallelic gene expression refers to the transcription of a gene from
one of two homologous alleles. We assessed the dynamics of monoallelic expression during …

The pluripotent nature of embryonic stem cells (ESC) is associated with a dynamic open
chromatin state and an irregular nuclear shape. It has been postulated that the absence of …