Genome-editing tools, and in particular those based on CRISPR–Cas (clustered regularly
interspaced short palindromic repeat (CRISPR)–CRISPR-associated protein) systems, are …

Multinational companies (MNCs) combine the advantages of global strategies with
embeddedness in heterogeneous social, and especially national, contexts. This embeddedness …

… salt concentration (for example, 2 to 7 M) further drove reentrant phase separation in a different
… Heidenreich, M. et al. Designer protein assemblies with tunable phase diagrams in living …

… Martin Heidenreich & Gerhard Krauss … The Baden-Württemberg case, represented in
Krauss & Heidenreich’s chapter here, is comparable in that two culturally different entities …

CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre-…

The dynamic nature of gene expression enables cellular programming, homeostasis and
environmental adaptation in living systems. Dissection of causal gene functions in cellular and …

Targeting of multiple genomic loci with Cas9 is limited by the need for multiple or large
expression constructs. Here we show that the ability of Cpf1 to process its own CRISPR RNA (…

Probing gene function in the mammalian brain can be greatly assisted with methods to
manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short …

Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …

Single-cell RNA sequencing (RNA-Seq) provides rich information about cell types and
states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, …