10.7554/eLife.10956.001 Women live on average longer than men but have greater levels
of late-life morbidity. We have uncovered a substantial sex difference in the pathology of the …

Intermittent fasting (IF) can improve function and health during aging in laboratory model
organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila …

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for
the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current …

Chimeric antigen receptor (CAR)-T cell therapies have demonstrated strong curative potential
and become a critical component in the array of B-cell malignancy treatments. Successful …

Autologous CD19/CD20 bispecific CAR-T cell therapy generated from T N/MEM cells for
patients with NHL is safe (no neurotoxicity, maximum grade 1 cytokine release syndrome) and …

… Lithium chloride solution was made at 10 M concentration and added to 200 μM RU486 …
, the pellet washed twice with acetone and re-suspended in 200 μl of 4 M guanidine-HCl. …

Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet
the underlying biology remains unclear. We show that the anti-aging effects of rapamycin …

Pharmacological therapies are promising interventions to slow down aging and reduce
multimorbidity in the elderly. Studies in animal models are the first step toward translation of …

Several species of β-amyloid peptides (Aβ) exist as a result of differential cleavage from
amyloid precursor protein (APP) to yield various C-terminal Aβ peptides. Several N-terminal …

… T N/M cells, which have more recently been shown to exhibit clinical potential as a highly
functional starting population for therapeutic T-cell manufacturing (NCT04007029), were used …