Predicting evolution

M Lässig, V Mustonen, AM Walczak - Nature ecology & evolution, 2017 - nature.com
The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Fitness flux and ubiquity of adaptive evolution

V Mustonen, M Lässig - Proceedings of the National …, 2010 - National Acad Sciences
Natural selection favors fitter variants in a population, but actual evolutionary processes may
decrease fitness by mutations and genetic drift. How is the stochastic evolution of molecular …

On the renormalization of the Kardar-Parisi-Zhang equation

M Lässig - Nuclear Physics B, 1995 - Elsevier
… I will therefore denote all quantities in the minimal subtraction scheme by the subscript M,
and reserve the term "… More generally, we define the normal-ordered m-line contact fields …

On growth, disorder, and field theory

M Lässig - Journal of physics: Condensed matter, 1998 - iopscience.iop.org
… We focus on the temperature dependence of the scales ξ(m). For fixed g, ξ(m) is
monotonically increasing with temperature according to (3.61). This is not surprising since it is …

[PDF][PDF] Stochastic evolution of transcription factor binding sites

J Berg, M Lassig - Biophysics, 2003 - thp.uni-koeln.de
A key step in the process of genetic transcription is the binding of one or several transcription
factors to specific sites in the regulatory region of a gene. These binding sites may differ …

From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation

V Mustonen, M Lässig - Trends in genetics, 2009 - cell.com
Evolution is a quest for innovation. Organisms adapt to changing natural selection by evolving
new phenotypes. Can we read this dynamics in their genomes? Not every mutation under …

Clonal interference in the evolution of influenza

N Strelkowa, M Lässig - Genetics, 2012 - academic.oup.com
The seasonal influenza A virus undergoes rapid evolution to escape human immune response.
Adaptive changes occur primarily in antigenic epitopes, the antibody-binding domains of …

The scaling region of the tricritical Ising model in two dimensions

M Lässig, G Mussardo, JL Cardy - Nuclear Physics B, 1991 - Elsevier
… of stable particles above threshold with fixed mass ratios m;/m, [9,26,181, and this requires
fine… 2 we can read off the order of magnitude of such matrix elements to be M- 10-'m 1. But the …

Predictive modeling of influenza shows the promise of applied evolutionary biology

…, M Łuksza, RA Neher, BT Grenfell, M Lässig… - Trends in …, 2018 - cell.com
Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza
virus antigens means that vaccines must be updated to match novel strains, and vaccine …

[PDF][PDF] Population immunity predicts evolutionary trajectories of SARS-CoV-2

…, D Ruchnewitz, J Eberhardt, M Łuksza, M Lässig - Cell, 2023 - cell.com
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of
genetic clades. New variants show intrinsic changes, notably increased transmissibility, and …