Predicting evolution
M Lässig, V Mustonen, AM Walczak - Nature ecology & evolution, 2017 - nature.com
The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …
predicting future evolutionary processes. Recent developments include prediction of …
Fitness flux and ubiquity of adaptive evolution
V Mustonen, M Lässig - Proceedings of the National …, 2010 - National Acad Sciences
Natural selection favors fitter variants in a population, but actual evolutionary processes may
decrease fitness by mutations and genetic drift. How is the stochastic evolution of molecular …
decrease fitness by mutations and genetic drift. How is the stochastic evolution of molecular …
On the renormalization of the Kardar-Parisi-Zhang equation
M Lässig - Nuclear Physics B, 1995 - Elsevier
… I will therefore denote all quantities in the minimal subtraction scheme by the subscript M,
and reserve the term "… More generally, we define the normal-ordered m-line contact fields …
and reserve the term "… More generally, we define the normal-ordered m-line contact fields …
On growth, disorder, and field theory
M Lässig - Journal of physics: Condensed matter, 1998 - iopscience.iop.org
… We focus on the temperature dependence of the scales ξ(m). For fixed g, ξ(m) is
monotonically increasing with temperature according to (3.61). This is not surprising since it is …
monotonically increasing with temperature according to (3.61). This is not surprising since it is …
[PDF][PDF] Stochastic evolution of transcription factor binding sites
J Berg, M Lassig - Biophysics, 2003 - thp.uni-koeln.de
A key step in the process of genetic transcription is the binding of one or several transcription
factors to specific sites in the regulatory region of a gene. These binding sites may differ …
factors to specific sites in the regulatory region of a gene. These binding sites may differ …
From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation
V Mustonen, M Lässig - Trends in genetics, 2009 - cell.com
Evolution is a quest for innovation. Organisms adapt to changing natural selection by evolving
new phenotypes. Can we read this dynamics in their genomes? Not every mutation under …
new phenotypes. Can we read this dynamics in their genomes? Not every mutation under …
Clonal interference in the evolution of influenza
N Strelkowa, M Lässig - Genetics, 2012 - academic.oup.com
The seasonal influenza A virus undergoes rapid evolution to escape human immune response.
Adaptive changes occur primarily in antigenic epitopes, the antibody-binding domains of …
Adaptive changes occur primarily in antigenic epitopes, the antibody-binding domains of …
The scaling region of the tricritical Ising model in two dimensions
M Lässig, G Mussardo, JL Cardy - Nuclear Physics B, 1991 - Elsevier
… of stable particles above threshold with fixed mass ratios m;/m, [9,26,181, and this requires
fine… 2 we can read off the order of magnitude of such matrix elements to be M- 10-'m 1. But the …
fine… 2 we can read off the order of magnitude of such matrix elements to be M- 10-'m 1. But the …
Predictive modeling of influenza shows the promise of applied evolutionary biology
Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza
virus antigens means that vaccines must be updated to match novel strains, and vaccine …
virus antigens means that vaccines must be updated to match novel strains, and vaccine …
[PDF][PDF] Population immunity predicts evolutionary trajectories of SARS-CoV-2
…, D Ruchnewitz, J Eberhardt, M Łuksza, M Lässig - Cell, 2023 - cell.com
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of
genetic clades. New variants show intrinsic changes, notably increased transmissibility, and …
genetic clades. New variants show intrinsic changes, notably increased transmissibility, and …