Background Stroke thrombolysis with alteplase is currently recommended 0–4·5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Recent case-series of small size implied a pathophysiological association between coronavirus
disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that …

Purpose Inscrutable machine learning (ML) models are part of increasingly many information
systems. Understanding how these models behave, and what their output is based on, is a …

Background The effect of early as compared with later initiation of direct oral anticoagulants (DOACs)
in persons with atrial fibrillation who have had an acute ischemic stroke is unclear. …

Genome-wide association studies have identified numerous loci linked with complex diseases,
for which the molecular mechanisms remain largely unclear. Comprehensive molecular …

Background— High-throughput profiling of circulating metabolites may improve cardiovascular
risk prediction over established risk factors. Methods and Results— We applied …

Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …

Background Guidelines recommend normocapnia for adults with coma who are resuscitated
after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood …

Blood lipids and metabolites are markers of current health and future disease risk. Here, we
describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 …

Background and purpose Patients with acquired brain injury and acute or prolonged disorders
of consciousness (DoC) are challenging. Evidence to support diagnostic decisions on …