Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-releasing
activity. This activity is mediated by the activation of the so-called GH secretagogue …

… a body mass index (BMI) of 30–34.9 kg m –2 carry a hazard ratio for overall mortality that is
elevated by more than 40% and at a BMI > 40 kg m –2 the relative rate increases to 100% 5 . …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

… Obesity was defined as BMI >30 kg/m 2 , according to the criteria of both the World Health
Organization and the International Obesity Task Force. All participants were between 20 and …

The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via
hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized …

Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …

Objective Ghrelin is a new gastric hormone that has been identified as an endogenous
ligand for the growth hormone (GH) secretagogue receptor subtype 1a (GHS-R1a). Ghrelin …

The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids,
are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with …

The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin
receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic …

The novel hormone ghrelin is a potent orexigen that may counterbalance leptin. Ghrelin is
the only secreted molecule requiring post-translational acylation with octanoic acid to ensure …