User profiles for M. Tuke

Marcus A Tuke

University of Exeter
Verified email at exeter.ac.uk
Cited by 7460

The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans

GE Kempson, H Muir, C Pollard, M Tuke - Biochimica et Biophysica Acta …, 1973 - Elsevier
A method is described of measuring the tensile stiffness and fracture stress of human femoral
condylar cartilage in planes parallel to and at increasing depth below the articular surface. …

[HTML][HTML] Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

…, HS Dashti, M Hillsdon, KS Ruth, MA Tuke… - Nature …, 2019 - nature.com
Being a morning person is a behavioural indicator of a person’s underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we …

Genome-wide associations for birth weight and correlations with adult disease

…, M Nodzenski, LA Diver, KT Zondervan, M Bustamante… - Nature, 2016 - nature.com
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

…, M Vaudel, CJ Marsit, J Chen, M Nodzenski… - Nature …, 2019 - nature.com
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank

…, CM Astley, R Lovell, H Yaghootkar, M Tuke… - bmj, 2016 - bmj.com
Objective To determine whether height and body mass index (BMI) have a causal role in
five measures of socioeconomic status. Design Mendelian randomisation study to test for …

[HTML][HTML] Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci

…, MA Tuke, H Yaghootkar, Y Hu, M Teder-Laving… - PLoS …, 2016 - journals.plos.org
Disrupted circadian rhythms and reduced sleep duration are associated with several human
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …

Edge loading in third generation alumina ceramic-on-ceramic bearings: stripe wear

WL Walter, GM Insley, WK Walter, MA Tuke - The Journal of arthroplasty, 2004 - Elsevier
Alumina ceramic-on-ceramic bearings perform exceptionally well under standard hip simulator
conditions, but in vivo some retrieved bearings have shown an unusual stripe pattern of …

[HTML][HTML] Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

…, RN Beaumont, M Hillsdon, KS Ruth, MA Tuke… - Nature …, 2019 - nature.com
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer
data from 85,670 UK Biobank participants, we perform a genome-wide association …

Gene–obesogenic environment interactions in the UK Biobank study

…, RN Beaumont, SE Jones, MA Tuke… - International journal …, 2017 - academic.oup.com
… We performed analyses of BMI on both its natural (kg/m 2 ) … kg/m 2 , and 95% had a BMI
between 21.3 and 37.3 kg/m 2 (a … kg/m 2 , and 95% had a BMI between 21.9 and 34.7 kg/m 2 (a …

Using genetics to understand the causal influence of higher BMI on depression

…, A Zhou, RN Beaumont, MA Tuke… - International journal …, 2019 - academic.oup.com
Background Depression is more common in obese than non-obese individuals, especially
in women, but the causal relationship between obesity and depression is complex and …