User profiles for N. C. Knox

Natalie C Knox

Public Health Agency of Canada
Verified email at canada.ca
Cited by 2172

[HTML][HTML] Metagenomics: the next culture-independent game changer

JD Forbes, NC Knox, J Ronholm, F Pagotto… - Frontiers in …, 2017 - frontiersin.org
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories
is at a crossroads with the ability of public health agencies to perform their basic mandate of …

The gut microbiome as a target for IBD treatment: are we there yet?

NC Knox, JD Forbes, G Van Domselaar… - … treatment options in …, 2019 - Springer
Purpose of review This review aims to highlight recent research on the gut microbiome in IBD
and the application of microbiome-modulating therapies for the treatment of IBD including …

[HTML][HTML] A fungal world: could the gut mycobiome be involved in neurological disease?

…, H Tremlett, G Van Domselaar, NC Knox - Frontiers in …, 2019 - frontiersin.org
The human microbiome has received decades of attention from scientific and medical
research communities. The human gastrointestinal tract is host to immense populations of …

[HTML][HTML] A comparative study of the gut microbiota in immune-mediated inflammatory diseases—does a common dysbiosis exist?

JD Forbes, C Chen, NC Knox, RA Marrie… - Microbiome, 2018 - Springer
Background Immune-mediated inflammatory disease (IMID) represents a substantial health
concern. It is widely recognized that IMID patients are at a higher risk for developing …

SNVPhyl: a single nucleotide variant phylogenomics pipeline for microbial genomic epidemiology

A Petkau, P Mabon, C Sieffert, NC Knox… - Microbial …, 2017 - microbiologyresearch.org
The recent widespread application of whole-genome sequencing (WGS) for microbial
disease investigations has spurred the development of new bioinformatics tools, including a …

[HTML][HTML] A comparison of whole genome sequencing of SARS-CoV-2 using amplicon-based sequencing, random hexamers, and bait capture

…, A Banerjee, H Mbareche, BP Alcock, NC Knox… - Viruses, 2020 - mdpi.com
Genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
increasingly important to monitor the transmission and adaptive evolution of the virus. The …

The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes

…, JD Forbes, M Graham, J Hart, NC Knox… - Annals of clinical …, 2021 - Wiley Online Library
Objective To examine the gut microbiota in individuals with and without pediatric‐onset
multiple sclerosis (MS). Methods We compared stool‐derived microbiota of Canadian Pediatric …

The gut microbiome in inflammatory bowel disease: lessons learned from other immune-mediated inflammatory diseases

NC Knox, JD Forbes, CL Peterson… - Official journal of the …, 2019 - journals.lww.com
There is a growing appreciation for the role of the gut microbiome in human health and disease.
Aided by advances in sequencing technologies and analytical methods, recent research …

[HTML][HTML] Highlighting clinical metagenomics for enhanced diagnostic decision-making: a step towards wider implementation

JD Forbes, NC Knox, CL Peterson… - Computational and …, 2018 - Elsevier
Clinical metagenomics (CMg) is the discipline that refers to the sequencing of all nucleic
acid material present within a clinical specimen with the intent to recover clinically relevant …

[HTML][HTML] Comparison of Sample Preparation Methods Used for the Next-Generation Sequencing of Mycobacterium tuberculosis

AD Tyler, S Christianson, NC Knox, P Mabon, J Wolfe… - PLoS …, 2016 - journals.plos.org
The advent and widespread application of next-generation sequencing (NGS) technologies
to the study of microbial genomes has led to a substantial increase in the number of studies …