Histone modifications influence the interactions of transcriptional regulators with chromatin.
Studies in embryos and embryonic stem (ES) cells have uncovered histone modification …

The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the zygotic …

Long noncoding RNAs (lncRNAs) comprise a diverse class of transcripts that structurally
resemble mRNAs but do not encode proteins. Recent genome-wide studies in humans and the …

After fertilization the embryonic genome is inactive until transcription is initiated during the
maternal–zygotic transition 1 , 2 , 3 . This transition coincides with the formation of pluripotent …

Small RNA molecules participate in a variety of activities in the cell: in a process known as
RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA …

… Author links open overlay panel Máté Pálfy , Shai R Joseph , Nadine L Vastenhouw … We
thank members of the Vastenhouw laboratory for discussions, and Lennart Hilbert and Iain …

Transposon jumps are a major cause of genome instability. In the C. elegans strain Bristol
N2, transposons are active in somatic cells, but they are silenced in the germline [1], …

… to 0.2 mg/ml in H 2 O, and 1 nl of this solution was injected into embryos at the single-cell
stage to deliver 0.2 ng of α-amanitin 75 . Control embryos were injected with 1 nl of H 2 O. …

10.7554/eLife.23326.001 Upon fertilization, the genome of animal embryos remains
transcriptionally inactive until the maternal-to-zygotic transition. At this time, the embryo takes control …

10.7554/eLife.27240.001 In light microscopy, refractive index mismatches between media
and sample cause spherical aberrations that often limit penetration depth and resolution. …