Background: The morbidity associated with liver transplantation and major hepatic resections
is partly a result of ischemia-reperfusion injury. Data Sources: The entire world literature on …

Introduction. The development augmented reality devices allow physicians to incorporate
data visualization into diagnostic and treatment procedures to improve work efficiency, safety, …

Targeted delivery of oligonucleotides to liver hepatocytes using N-acetylgalactosamine (GalNAc)
conjugates that bind to the asialoglycoprotein receptor has become a breakthrough …

Functional elucidation of causal genetic variants and elements requires precise genome
editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short …

Systematic interrogation of gene function requires the ability to perturb gene expression in a
robust and generalizable manner. Here we describe structure-guided engineering of a …

Epigenetic information can be inherited through the mammalian germline and represents a
plausible transgenerational carrier of environmental information. To test whether …

Though many individual transcription factors are known to regulate hematopoietic differentiation,
major aspects of the global architecture of hematopoiesis remain unknown. Here, we …

N6-methyladenosine (m6A) is a common modification of mRNA with potential roles in fine-tuning
the RNA life cycle. Here, we identify a dense network of proteins interacting with …

… Asterisks denote statistically significant differences between AD and WT (n = 8 animals;
statistical test … Avraham-Davidi and members of the Habib laboratory for discussions and helpful …

Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …