User profiles for N. Ignatiadis

Nikolaos Ignatiadis

Statistics & Data Science, University of Chicago
Verified email at uchicago.edu
Cited by 1001

Data-driven hypothesis weighting increases detection power in genome-scale multiple testing

N Ignatiadis, B Klaus, JB Zaugg, W Huber - Nature methods, 2016 - nature.com
Hypothesis weighting improves the power of large-scale multiple testing. We describe
independent hypothesis weighting (IHW), a method that assigns weights using covariates …

[HTML][HTML] Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution

LG Karacosta, B Anchang, N Ignatiadis… - Nature …, 2019 - nature.com
… downsampled state (E1 cells n = 2394, E2 cells n = 3284, E3 cells n = 1316, pEMT1 cells …
transition distributions (bootstrap analysis based on n = 10,000 cells for each of seven …

Covariate powered cross-weighted multiple testing

N Ignatiadis, W Huber - Journal of the Royal Statistical Society …, 2021 - academic.oup.com
… Hence we build upon the hypothesis-splitting idea of Ignatiadis et al. (2016) and demonstrate
that it can be used not merely as a heuristic, but instead as a theoretically grounded and …

Net benefit, calibration, threshold selection, and training objectives for algorithmic fairness in healthcare

…, A Foryciarz, N Ignatiadis, J Genkins, N Shah - Proceedings of the …, 2022 - dl.acm.org
A growing body of work uses the paradigm of algorithmic fairness to frame the development
of techniques to anticipate and proactively mitigate the introduction or exacerbation of health …

E-values as unnormalized weights in multiple testing

N Ignatiadis, R Wang, A Ramdas - Biometrika, 2023 - academic.oup.com
We study how to combine p-values and e-values, and design multiple testing procedures
where both p-values and e-values are available for every hypothesis. Our results provide a …

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange

R Beer, K Herbst, N Ignatiadis, I Kats, L Adlung… - Molecular …, 2014 - pubs.rsc.org
… The number of data points for calibration was N = 714. (c) A boxplot of the distribution of
best estimates for parameter values obtained for the four IndC variants. (d) A surface plot color-…

Noise-induced randomization in regression discontinuity designs

D Eckles, N Ignatiadis, S Wager, H Wu - arXiv preprint arXiv:2004.09458, 2020 - arxiv.org
… Further suppose that the sequence of weighting kernels γ(n) … This dataset has scaled
mathematics test scores for n = 18, 174 children from kindergarten to fifth grade. Furthermore, each …

Treatment heterogeneity with survival outcomes

Y Xu, N Ignatiadis, E Sverdrup, S Fleming… - … of Matching and …, 2023 - taylorfrancis.com
This chapter is accompanied by survlearners, a package that provides well-documented
implementations of the conditional average treatment effects (CATE) estimation strategies …

Covariate-powered empirical Bayes estimation

N Ignatiadis, S Wager - Advances in Neural Information …, 2019 - proceedings.neurips.cc
We study methods for simultaneous analysis of many noisy experiments in the presence of
rich covariate information. The goal of the analyst is to optimally estimate the true effect …

Confidence intervals for nonparametric empirical Bayes analysis

N Ignatiadis, S Wager - Journal of the American Statistical …, 2022 - Taylor & Francis
… In Section 2 we explain how for common choices of G and F n ( α ) , (7) can be computed by
n = F n ( α n ) with α n → 0 and a pilot estimate f n ( · ) of the marginal density f G ( · ) (5). F n