Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine.
Here, we review data and technologies that have revealed intra-tumor heterogeneity …

Recent studies have revealed extensive genetic diversity both between and within tumours.
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a …

Precision medicine requires an understanding of cancer genes and mutational processes,
as well as an appreciation of the extent to which these are found heterogeneously in cancer …

… In a study of lung cancer and melanoma, McGranahan et al. … We thank N. Hacohen and S.
Turajlic for helpful advice on … We thank N. Hacohen and S. Turajlic for helpful advice on the …

Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

… n = 37, grey vertical lines represent range of clonal VAF, red shading indicates 95% … of
the number of total molecules X n and number of error molecules E n after n PCR cycles. …

Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome
segregation during mitosis. Although chromosomal instability is a major driver of tumour …

… We therefore investigated tumors with six distinct HLA alleles and loss of one HLA haplotype
(HLA-A, HLA-B, and HLA-C) in at least one tumor region (n = 20; 9 lung adenocarcinomas …

Spatial and temporal dissection of the genomic changes occurring during the evolution of
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal …

… to n biopsies (where n was the number of biopsies sampled from that tumor), taking into
account all permutations of the available biopsies (Supplementary Fig. 2). Although mutation …