User profiles for N. Välimäki
Niko VälimäkiPostdoctoral researcher, University of Helsinki Verified email at cs.helsinki.fi Cited by 3618 |
CTCF/cohesin-binding sites are frequently mutated in cancer
… The median sequencing coverage at non-N reference sequence was >40×. … ) 21 (version
0.6.2) with the parameters -n 0.06 and -q 5. PCR duplicates were removed using SAMtools (…
0.6.2) with the parameters -n 0.06 and -q 5. PCR duplicates were removed using SAMtools (…
[HTML][HTML] The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera
…, N Välimäki, L Paulin, J Kvist, N Wahlberg… - Nature …, 2014 - nature.com
… , which has the putative ancestral karyotype of n=31. Using a phylogenetic analyses of … ,
we conclude that the ancestral lepidopteran karyotype has been n=31 for at least 140 My. We …
we conclude that the ancestral lepidopteran karyotype has been n=31 for at least 140 My. We …
Indexing graphs for path queries with applications in genome research
… For any string S½1;nŠ, we write jSj ¼ n to denote its length. A substring of S is written as
S½i; jŠ ¼ S½iŠÁÁÁS½jŠ. Important types of substrings include prefixes S½1; jŠ and suffixes …
S½i; jŠ ¼ S½iŠÁÁÁS½jŠ. Important types of substrings include prefixes S½1; jŠ and suffixes …
[HTML][HTML] Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
… The frequency support vector has N entries, each being the number of … N 2 M) where N
is number of samples and M is number of k-mers, but can be parallelized across up to N …
is number of samples and M is number of k-mers, but can be parallelized across up to N …
Storage and retrieval of highly repetitive sequence collections
… The solution is not as space-efficient as possible, since array SA requires n log n bits,
and the solution is not yet a self-index, since T is needed in order to solve the display query. …
and the solution is not yet a self-index, since T is needed in order to solve the display query. …
[HTML][HTML] Genetic and epigenetic characteristics of inflammatory bowel Disease–Associated colorectal cancer
… Chromosomal stability of the MSS IBD-CRCs was inspected using both nanopore WGS
data (n = 19) and single nucleotide polymorphism array data (n = 27). Numbers of somatic …
data (n = 19) and single nucleotide polymorphism array data (n = 27). Numbers of somatic …
[HTML][HTML] Combined analysis of variation in core, accessory and regulatory genome regions provides a super-resolution view into the evolution of bacterial populations
…, S Dunn, T Sreecharan, M Vehkala, N Välimäki… - PLoS …, 2016 - journals.plos.org
The use of whole-genome phylogenetic analysis has revolutionized our understanding of
the evolution and spread of many important bacterial pathogens due to the high resolution …
the evolution and spread of many important bacterial pathogens due to the high resolution …
[HTML][HTML] Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis
…, A Baig, KJ Howell, M Vehkala, N Välimäki… - Nature …, 2015 - nature.com
Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in
zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. …
zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. …
Global and regional dissemination and evolution of Burkholderia pseudomallei
…, MTG Holden, M Vehkala, N Välimäki… - Nature …, 2017 - nature.com
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases
of human melioidosis per year worldwide and is also classified as a biothreat agent. We …
of human melioidosis per year worldwide and is also classified as a biothreat agent. We …
Early Alzheimer's disease pathology in human cortex involves transient cell states
…, A Pelkonen, M Gomez-Budia, NN Välimäki… - Cell, 2023 - cell.com
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a …
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a …