User profiles for O. K. Smith

Owen Smith

Stanford University School of Medicine
Verified email at stanford.edu
Cited by 841

A general equation for relaxation oscillations

N Levinson, OK Smith - 1942 - projecteuclid.org
SMITHSMITH … This method has been used by one of the authors, OK Smith, in his
thesis at MI T. (May, 1941) toprove Theorem I in a more restrictive form and with g(x) …

Chromatin structure and replication origins: determinants of chromosome replication and nuclear organization

OK Smith, MI Aladjem - Journal of Molecular Biology, 2014 - Elsevier
The DNA replication program is, in part, determined by the epigenetic landscape that governs
local chromosome architecture and directs chromosome duplication. Replication must …

DiMeLo-seq: a long-read, single-molecule method for mapping protein–DNA interactions genome wide

N Altemose, A Maslan, OK Smith, K Sundararajan… - Nature …, 2022 - nature.com
Studies of genome regulation routinely use high-throughput DNA sequencing approaches
to determine where specific proteins interact with DNA, and they rely on DNA amplification …

Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

JC Bell, D Jukam, NA Teran, VI Risca, OK Smith… - Elife, 2018 - elifesciences.org
10.7554/eLife.27024.001 RNA is a critical component of chromatin in eukaryotes, both as a
product of transcription, and as an essential constituent of ribonucleoprotein complexes that …

Eigenvalues of a symmetric 3× 3 matrix

OK Smith - Communications of the ACM, 1961 - dl.acm.org
Recently, in order to find the principal moments of inertia of a large number of rigid bodies, it
was necessary to compute the eigenvalues of many real, symmetric 3 × 3 matrices. The …

[HTML][HTML] Distinct epigenetic features of differentiation-regulated replication origins

OK Smith, RG Kim, H Fu, MM Martin, CM Lin… - Epigenetics & …, 2016 - Springer
Background Eukaryotic genome duplication starts at discrete sequences (replication origins)
that coordinate cell cycle progression, ensure genomic stability and modulate gene …

Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability

…, H Fu, SM Jang, AB Marks, OK Smith… - Nucleic acids …, 2017 - academic.oup.com
Chromatin structure affects DNA replication patterns, but the role of specific chromatin modifiers
in regulating the replication process is yet unclear. We report that phosphorylation of the …

[HTML][HTML] Global mapping of RNA-chromatin contacts reveals a proximity-dominated connectivity model for ncRNA-gene interactions

C Limouse, OK Smith, D Jukam, KA Fryer… - Nature …, 2023 - nature.com
Non-coding RNAs (ncRNAs) are transcribed throughout the genome and provide regulatory
inputs to gene expression through their interaction with chromatin. Yet, the genomic targets …

[HTML][HTML] The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin

…, K Utani, H Fu, CE Redon, AB Marks, OK Smith… - Nature …, 2018 - nature.com
Cell cycle progression in mammals is modulated by two ubiquitin ligase complexes, CRL4
and SCF, which facilitate degradation of chromatin substrates involved in the regulation of …

[HTML][HTML] Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs

…, AB Mudd, S Medina-Ruiz, T Mitros, OK Smith… - Nature …, 2024 - nature.com
Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians
that include important vertebrate cell and developmental model systems, notably the genus …