The kinetochore is a mega-dalton protein assembly that forms within centromeric regions of
chromosomes and directs their segregation during cell division. Here we review cell cycle-…

Polyploid cells are a characteristic feature of certain human tissues, and notably many cancers.
In a systematic genomic screen in yeast, Storchová and co-workers identified the genetic …

Hsp70 interactions are critical for cellular viability and the response to stress. Previous
attempts to characterize Hsp70 interactions have been limited by their transient nature and the …

Type I DNA restriction/modification enzymes protect the bacterial cell from viral infection by
cleaving foreign DNA which lacks N6-adenine methylation within a target sequence and …

Faithful chromosome segregation maintains chromosomal stability as errors in this process
contribute to chromosomal instability (CIN), which has been observed in many diseases …

Evolutionarily conserved polo-like kinase, Cdc5 (Plk1 in humans), associates with kinetochores
during mitosis; however, the role of cell cycle–dependent centromeric (CEN) association …

The location of proteins within eukaryotic cells is often critical for their function and relocation
of proteins forms the mainstay of regulatory pathways. To assess the importance of protein …

… lost by the radiation of internal waves [Thorpe, scenarios. Maslowe [1973] found a subcritical
1973a; Fritts, 1982b, 1984]. Finally, convection nonlinear development of billows at high Re…

Asymmetric cell division is of fundamental importance in biology as it allows for the establishment
of separate cell lineages during the development of multicellular organisms. Although …

The kinetochore, a multi-protein complex assembled on centromeres, is essential to
segregate chromosomes during cell division. Deficiencies in kinetochore function can lead to …