… C, the convulsant antagonist fipronil reduces the probability of channel openings (P o ) in
the S2-RDL cells, with addition of BIDN further reducing the P o . D, plotting the increasing …

… Here we focus on the core pore-forming domain (S5-P-S6 in Kv, homologous to M1-P-M2
in KcsA). There is significant sequence identity (ca. 30%) between KcsA and Kv in this region, …

Total (as opposed to culturable) bacterial number counts are reported for four sites in the
United Kingdom measured during campaigns over four separate seasons. These are …

Nicotinic acetylcholine receptors (nAChRs) are important for fast synaptic cholinergic
transmission. They are targets of drugs/chemicals for human and animal health as well as for pest …

This study investigated the role of the complement activation fragment C5a in secondary
pathology following contusive spinal cord injury (SCI). C5ar −/− mice, which lack the signaling …

Cecropins are positively charged antibacterial peptides that act by permeating the membrane
of susceptible bacteria. To gain insight into the mechanism of membrane permeation, the …

… = 7 and 10 Å, the channel is fully open if the length of the pore L P = 8 Å but fully closed if L
P = 12 Å. Overall, a hydrophobic pore can be switched from closed to open by increasing its …

Accurate prediction of binding affinities has been a central goal of computational chemistry
for decades, yet remains elusive. Despite good progress, the required accuracy for use in a …

Street dustshave been sampled at a variety of sites in En-gland. The highe st concentrations
of lead were often found in the smallest (< 38 pm) size fraction, with lower concentra-tions …

… Red dots: > 1.5 upregulated in the first sample mentioned above graph (p < 0.05); blue dots:
> 1.5 downregulated in the first sample mentioned above graph (p < 0.05). (g) Absence of …