Renal fibrosis: novel insights into mechanisms and therapeutic targets

P Boor, T Ostendorf, J Floege - Nature Reviews Nephrology, 2010 - nature.com
p | Increased formation of lymphatic vessels in the cortex can be noted in kidneys of fibrotic
mice with progressive glomerulonephritis. Original magnification ×100 (e–g, i–k), ×200 (a–d, …

Oleander toxicity: an examination of human and animal toxic exposures

SD Langford, PJ Boor - Toxicology, 1996 - Elsevier
The oleander is an attractive and hardy shrub that thrives in tropical and subtropical regions.
The common pink oleander, Nerium oleander, and the yellow oleander, Thevetia peruviana…

Cellular and molecular mechanisms of kidney fibrosis

S Djudjaj, P Boor - Molecular aspects of medicine, 2019 - Elsevier
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney injury
or maladaptive repair. It is considered as the underlying pathological process of chronic …

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

…, D Jäger, J Krause, SH Loosen, A Marx, P Boor… - Nature medicine, 2019 - nature.com
P values are listed in Supplementary Table 4. Sample sizes per cohort are: TCGA-STAD n
= 91, TCGA-CRC-… The P value was calculated by two-sided log-rank test (n = 350 patients). …

Decoding myofibroblast origins in human kidney fibrosis

…, M Klaus, L Gernhold, VG Puelles, TB Huber, P Boor… - Nature, 2021 - nature.com
… Adjusted P values for hypergeometric test for fibroblast and myofibroblast = 0; for pericyte
and vSMCs = 1. k, Diffusion mapping of mesenchymal cells. Pseudotime indicates cell …

[PDF][PDF] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

…, MF Schreuder, N Sommerdijk, A Akiva, P Boor… - Cell Stem Cell, 2022 - cell.com
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether
this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney …

Pan-cancer image-based detection of clinically actionable genetic alterations

…, JJ Schulte, NA Cipriani, RD Buelow, P Boor… - Nature cancer, 2020 - nature.com
… all P values across all cancer types. All P values smaller than 10 –5 after FDR correction
are reported as 10 −5 . Statistical methods are further described in Extended Data Fig. 10a–c. …

[HTML][HTML] Clinical-grade detection of microsatellite instability in colorectal tumors by deep learning

…, J Chang-Claude, C Trautwein, AT Pearson, P Boor… - Gastroenterology, 2020 - Elsevier
Background & Aims Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR)
in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI …

Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis

U Kunter, S Rong, Z Djuric, P Boor, G Mu… - Journal of the American …, 2006 - journals.lww.com
… in MSC-treated left kidneys as compared with right internal control kidneys (P < 0.05) but
not in comparison with medium-treated left kidneys (P = 0.06; Figure 6). As in Wistar rats, none …

[HTML][HTML] Spatial multi-omic map of human myocardial infarction

…, M Morshuis, J Amrute, RJA Veltrop, P Boor… - Nature, 2022 - nature.com
Myocardial infarction is a leading cause of death worldwide 1 . Although advances have
been made in acute treatment, an incomplete understanding of remodelling processes has …