From association to prediction: statistical methods for the dissection and selection of complex traits in plants
… Given the number of markers (p) and sample size (n) in a typical diversity population, GS
models usually have more predictors than the sample size (a p ≫ n model), resulting in an …
models usually have more predictors than the sample size (a p ≫ n model), resulting in an …
Uncommon EGFR mutations in advanced non-small cell lung cancer
Molecular profiling in advanced non-small cell lung cancer (NSCLC) has allowed for the
detection of actionable mutations, which has revolutionized the treatment paradigm in this …
detection of actionable mutations, which has revolutionized the treatment paradigm in this …
TASSEL: software for association mapping of complex traits in diverse samples
… The first option provides some transformation functions which may produce roughly normal
error terms, while the second utilizes a permutation test to generate P-values that are not …
error terms, while the second utilizes a permutation test to generate P-values that are not …
GAPIT: genome association and prediction integrated tool
…, F Tian, Q Wang, J Peiffer, M Li, PJ Bradbury… - …, 2012 - academic.oup.com
Software programs that conduct genome-wide association studies and genomic prediction
and selection need to use methodologies that maximize statistical power, provide high …
and selection need to use methodologies that maximize statistical power, provide high …
Mixed linear model approach adapted for genome-wide association studies
… We compared P values obtained from using P3D to P values from using full optimization for
testing the association between observed phenotypes and markers in human, dog and maize…
testing the association between observed phenotypes and markers in human, dog and maize…
The genetic architecture of maize flowering time
Flowering time is a complex trait that controls adaptation of plants to their local environment
in the outcrossing species Zea mays (maize). We dissected variation for flowering time with a …
in the outcrossing species Zea mays (maize). We dissected variation for flowering time with a …
Genetic properties of the maize nested association mapping population
MD McMullen, S Kresovich, HS Villeda, P Bradbury… - Science, 2009 - science.org
Maize genetic diversity has been used to understand the molecular basis of phenotypic
variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred …
variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred …
Genome-wide association study of leaf architecture in the maize nested association mapping population
F Tian, PJ Bradbury, PJ Brown, H Hung, Q Sun… - Nature …, 2011 - nature.com
… We used this method to calculate a support interval (P < 0.05) for each joint QTL (Supplementary
Tables 1–3). QTLs were defined as colocalized if their support intervals (P < 0.05) …
Tables 1–3). QTLs were defined as colocalized if their support intervals (P < 0.05) …
Postoperative adjuvant systemic therapy in completely resected non–small-cell lung cancer: a systematic review
P Bradbury, D Sivajohanathan, A Chan, S Kulkarni… - Clinical lung cancer, 2017 - Elsevier
The purpose of the present review was to determine whether the use of postoperative
adjuvant systemic therapy in patients with completely resected non–small-cell lung cancer (NSCLC…
adjuvant systemic therapy in patients with completely resected non–small-cell lung cancer (NSCLC…
Genome-wide association study of quantitative resistance to southern leaf blight in the maize nested association mapping population
… We identified 32 SLB-resistance QTLs at P < 0.0001 in a joint linkage analysis across all
families (Fig. 2 and Supplementary Tables 2 and 3). The median length of the support intervals …
families (Fig. 2 and Supplementary Tables 2 and 3). The median length of the support intervals …