User profiles for P. Flicek

Paul Flicek

The Jackson Laboratory, University of Cambridge
Verified email at jax.org
Cited by 171995

Sense from sequence reads: methods for alignment and assembly

P Flicek, E Birney - Nature methods, 2009 - nature.com
… Caccomo and P. Flicek, unpublished data). ABySS works using a message-passing interface
(MPI)-cluster approach, whereas SOAP and Cortex use multiple passes over compressed …

[HTML][HTML] The Human Pangenome Project: a global resource to map genomic diversity

…, BI Schultz, MW Smith, HJ Sofia, T Weissman, P Flicek… - Nature, 2022 - nature.com
The human reference genome is the most widely used resource in human genetics and is
due for a major update. Its current structure is a linear composite of merged haplotypes from …

Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences

…, GR Abecasis, SA McCarroll, P Flicek… - Nature …, 2016 - nature.com
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26
worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 …

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

…, L Barrera, R Stuart, D Zheng, S Ghosh, P Flicek… - nature, 2007 - nature.com
We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Ensembl 2022

…, KL Howe, AD Yates, DR Zerbino, P Flicek - Nucleic acids …, 2022 - academic.oup.com
Ensembl ( https://www.ensembl.org ) is unique in its flexible infrastructure for access to genomic
data and annotation. It has been designed to efficiently deliver annotation at scale for all …

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

…, SJ Trevanion, P Hall, H Junkins, P Flicek… - Nucleic acids …, 2019 - academic.oup.com
… Full P-value SS are defined as the aggregate P-values and association data for every … user
queries; for example, retrieving P-values and associated fields, P-value plus the effect allele …

Ensembl 2021

…, AD Yates, DR Zerbino, P Flicek - Nucleic acids …, 2021 - academic.oup.com
The Ensembl project ( https://www.ensembl.org ) annotates genomes and disseminates
genomic data for vertebrate species. We create detailed and comprehensive annotation of gene …

[HTML][HTML] Towards complete and error-free genome assemblies of all vertebrate species

…, P Masterson, K Clark, F Martin, K Howe, P Flicek… - Nature, 2021 - nature.com
High-quality and complete reference genome assemblies are fundamental for the application
of genomics to biology, disease, and biodiversity conservation. However, such assemblies …

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

…, P Hall, H Junkins, A Klemm, P Flicek… - Nucleic acids …, 2014 - academic.oup.com
… of PubMed, tracking of papers through the curatorial pipeline and, for eligible papers,
automatic extraction of citation information and batch extraction of SNP RSIDs, traits and P-value …

Ensembl 2018

…, BL Aken, F Cunningham, A Yates, P Flicek - Nucleic acids …, 2018 - academic.oup.com
The Ensembl project has been aggregating, processing, integrating and redistributing
genomic datasets since the initial releases of the draft human genome, with the aim of …