User profiles for P. Freemont
 | Paul FreemontProfessor of Protein Crystallography, Imperial College London Verified email at imperial.ac.uk Cited by 29914 |
Does this have a familiar RING?
… Email: freemont@icrf.icnet.uk KLB Borden is at the Department of Biochemistry, Faculty of
… 34 Arenavirus protein involved in viral mRNA and DNA replication p Required for viral DNA …
… 34 Arenavirus protein involved in viral mRNA and DNA replication p Required for viral DNA …
[PDF][PDF] Ubiquitination: RING for destruction?
PS Freemont - Current Biology, 2000 - cell.com
Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein
function. Recent results implicate the RING finger domain in specific ubiquitination events; it is …
function. Recent results implicate the RING finger domain in specific ubiquitination events; it is …
The RING finger domain: a recent example of a sequence—structure family
KLB Borden, PS Freemont - Current opinion in structural biology, 1996 - Elsevier
… , where Cys3 is substituted with a threonine residue [19], retinoblastoma binding protein
Q1 (RBQ-1), where Hisl is substituted with an asparagine residue (AJ Saurin, PS Freemont, …
Q1 (RBQ-1), where Hisl is substituted with an asparagine residue (AJ Saurin, PS Freemont, …
[HTML][HTML] Community transmission and viral load kinetics of the SARS-CoV-2 delta (B. 1.617. 2) variant in vaccinated and unvaccinated individuals in the UK: a …
…, E Conibear, W Barclay, PS Freemont… - The lancet infectious …, 2022 - thelancet.com
Background The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading
globally, including in populations with high vaccination rates. We aimed to investigate …
globally, including in populations with high vaccination rates. We aimed to investigate …
Role of SUMO-1–modified PML in nuclear body formation
The tumor-suppressive promyelocytic leukemia (PML) protein of acute promyelocytic
leukemia (APL) has served as one of the defining components of a class of distinctive nuclear …
leukemia (APL) has served as one of the defining components of a class of distinctive nuclear …
Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as2O3-Induced Pml or Pml/Retinoic Acid Receptor …
Promyelocytic leukemia (PML) is the organizer of nuclear matrix domains, PML nuclear
bodies (NBs), with a proposed role in apoptosis control. In acute promyelocytic leukemia, PML/…
bodies (NBs), with a proposed role in apoptosis control. In acute promyelocytic leukemia, PML/…
[HTML][HTML] p47 is a cofactor for p97-mediated membrane fusion
…, R Newman, TP Levine, D Pappin, P Freemont… - Nature, 1997 - nature.com
At least two distinct ATPases, NSF and p97, are known to be involved in the heterotypic fusion
of transport vesicles with their target membranes and the homotypic fusion of membrane …
of transport vesicles with their target membranes and the homotypic fusion of membrane …
[PDF][PDF] Structure of the AAA ATPase p97
… A superposition of the p97 D1 and NSF D2 hexamers, based on their respective P loops,
shows that although established that P loops are involved in nucleotide binding, while the DExx …
shows that although established that P loops are involved in nucleotide binding, while the DExx …
PML protein isoforms and the RBCC/TRIM motif
K Jensen, C Shiels, PS Freemont - Oncogene, 2001 - nature.com
… Co-transfection studies of these mutants with PML-RARα however, prevents the formation
of PML-RARα speckles (E Duprez and P Freemont, unpublished observations), suggesting a …
of PML-RARα speckles (E Duprez and P Freemont, unpublished observations), suggesting a …
Co-culture systems and technologies: taking synthetic biology to the next level
Co-culture techniques find myriad applications in biology for studying natural or synthetic
interactions between cell populations. Such techniques are of great importance in synthetic …
interactions between cell populations. Such techniques are of great importance in synthetic …